Evidence map›Paper›PMID 37747811›Full record

ArticleHuman gene therapy2023

Vector-Mediated Delivery of Human Major Histocompatibility Complex-I into Hepatocytes Enables Investigation of T Cell Receptor-Redirected Hepatitis B Virus-Specific T Cells in Mice, and in Macaque Cell Cultures.

Julia Festag, Marvin M Festag, Theresa Asen, Jochen M Wettengel, Martin A Mück-Häusl, Shaheed Abdulhaqq, Christiane Stahl-Hennig, Jonah B Sacha, Benjamin J Burwitz, Ulrike Protzer and 1 more

Open access · greenAbstract read
In one paragraph

Article in Human gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Julia FestagInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Marvin M FestagInstitute of Virology, School of Medicine, Technical University of Munich, Munich, Germany.
Theresa AsenInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Jochen M WettengelInstitute of Virology, School of Medicine, Technical University of Munich, Munich, Germany.
Martin A Mück-HäuslInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.
Shaheed AbdulhaqqVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Christiane Stahl-HennigGerman Primate Center (DPZ), Göttingen, Germany.
Jonah B SachaVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Benjamin J BurwitzVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA.
Ulrike ProtzerInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.ORCID 0000-0002-9421-1911
Karin WisskirchenInstitute of Virology, Helmholtz Zentrum München, Munich, Germany.ORCID 0000-0002-7447-4044
Helmholtz Zentrum München · DEOregon National Primate Research Center · USTechnical University of Munich · DEGerman Primate Center · DEOregon Health & Science University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

Adoptive T cell therapy using natural T cell receptor (TCR) redirection is a promising approach to fight solid cancers and viral infections in liver and other organs. However, clinical efficacy of such TCR

Indexed as

Hepatitis B virusHepatocytesAnimalsCell Culture TechniquesHLA-A AntigensHumansMiceReceptors, Antigen, T-CellT-LymphocytesHLA-A AntigensReceptors, Antigen, T-CellAAV vectoradoptive T cell therapyhepatitis B virusHLA-A*02MHC-I moleculeprimary macaque hepatocytesprimary mouse hepatocytes

Identifiers

PMID37747811
PMCPMC10825313
OpenAlexW4387012451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.