Evidence map›Paper›PMID 37747682›Full record

ArticleMolecular biology reports2023

Oleuropein exhibits anticarcinogen effects against gastric cancer cell lines.

Mehmed Kürşad Türkdoğan, Abdurrahim Koçyiğit, Eray Metin Güler, Ömer Faruk Özer, Kübra Demir, Halime Uğur

Abstract read
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In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Regulatory Effects ofFood science & nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mehmed Kürşad TürkdoğanDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Sabahattin Zaim University, Istanbul, Turkey. kursad.turkdogan@izu.edu.tr.ORCID http://orcid.org/0000-0002-5594-782X
Abdurrahim KoçyiğitDepartment of Biochemistry, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
Eray Metin GülerDepartment of Medical Biochemistry, Hamidiye School of Medicine, University of Health Sciences, Istanbul, Turkey.
Ömer Faruk ÖzerDepartment of Biochemistry, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
Kübra DemirDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Sabahattin Zaim University, Istanbul, Turkey.
Halime UğurDepartment of Nutrition and Dietetics, Faculty of Health Sciences, İstanbul Medeniyet University, Istanbul, Turkey.
Bezmiâlem Vakıf Üniversitesi · TRİstanbul Sabahattin Zaim Üniversitesi · TRIstanbul Medeniyet University · TRSağlık Bilimleri Üniversitesi · TR

Funding

Bezmialem University Faculty of Medicine Scientific Research Project Fund 3.2014/35
6 · The paper itself

Abstract

backgroundOleuropein (OLE), the main phenolic compound of the olive fruit and leaves, has many heathful effects. Gastric cancer is the most fatal malignancy in many parts of the world and it is generally related to harmful dietetic factors. The anticarcinogenic role of OLE in gastric cancer has not been studied sufficiently yet. In this study, we aimed to research the cytotoxic, genotoxic and apoptotic effects of OLE on gastric adenocancer (AGS) cells in vitro. METHODS AND

resultsA standard cell line derived from gastric adeno cancer (AGS) cells was employed, and its performance following a 24-hour exposure to OLE at various doses was examined. The ATP cell viability assay, 2',7'-dichlorodihydrofluorescein-diacetate assay (H2DCF-DA) and alkaline single cell gel electrophoresis assay (Comet Assay) were used to study the cytotoxicity, production of reactive oxygen species (ROS) and genotoxicity respectively. The induction of apoptosis was discovered using flow cytometry. OLE reduced AGS cells viability about 60% at maximum concentration (500 µmol/L) and also resulted in approximately 100% DNA damage and about 40% apoptosis with necrosis in AGS cells depending on the increased doses. Cell viability was also significantly decreased in relation to increased intracellular reactive oxygen species (ROS) levels (p < 0.05 - 0.001).

conclusionsOleuropein has shown significant anticarcinogen effects against gastric adenocancer (AGS) cells in vitro. Oleuropein, a nutrient rich in olive and olive oil, seems to be both protective and therapeutic against gastric cancer and may be a new chemotherapeutic agent in the future.

Indexed as

Anticarcinogenic AgentsStomach NeoplasmsCell LineHumansIridoid GlucosidesReactive Oxygen SpeciesAnticarcinogenic AgentsIridoid GlucosidesoleuropeinReactive Oxygen SpeciesApoptosisDNA damageGastric cancerOleuropein

Identifiers

PMID37747682
OpenAlexW4387003285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.