Evidence map›Paper›PMID 37747540›Full record

ArticleImmunogenetics2023

Comparative genomics of the T cell receptor μ locus in marsupials and monotremes.

K A Morrissey, M R Stammnitz, E Murchison, R D Miller

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunogenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

K A MorrisseyCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico Albuquerque, Albuquerque, NM, USA.
M R StammnitzCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
E MurchisonTransmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
R D MillerCenter for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico Albuquerque, Albuquerque, NM, USA. rdmiller@unm.edu.ORCID 0000-0002-8479-8819
University of New Mexico · USCentre for Genomic Regulation · ESUniversity of Cambridge · GB

Funding

FAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M
NIGMS NIH HHS K12 GM088021Wellcome Trust 102942Wellcome Trust 102942/Z/13Wellcome Trust 102942/Z/13/AWellcome Trust 222551Wellcome Trust 222551/Z/21
6 · The paper itself

Abstract

T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based on their T cell receptors (TCR). The αβ T cells and γδ T cells are ancient and found broadly in vertebrates. The more recently discovered γμ T cells are uniquely mammalian and only found in marsupials and monotremes. In this study, we compare the TCRμ locus (TRM) across the genomes of two marsupials, the gray short-tailed opossum and Tasmanian devil, and one monotreme, the platypus. These analyses revealed lineage-specific duplications, common to all non-eutherian mammals described. There is conserved synteny in the TRM loci of both marsupials but not in the monotreme. Our results are consistent with an ancestral cluster organization which was present in the last common mammalian ancestor which underwent lineage-specific duplications and divergence among the non-eutherian mammals.

Indexed as

MarsupialiaPlatypusAnimalsEvolution, MolecularGenomicsMammalsPhylogenyReceptors, Antigen, T-CellReceptors, Antigen, T-CellMarsupialsMonotremesT cell receptor genes

Identifiers

PMID37747540
PMCPMC7615758
OpenAlexW4387003149

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.