Evidence map›Paper›PMID 37747202›Full record

ArticlemSphere2023

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues.

Kyle R Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G Oldenburg, J Craig Forrest, Kevin M McBride, Laurie T Krug

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Kyle R SmithHIV and AIDS Malignancy Branch, National Cancer Institute , Bethesda, Maryland, USA.
Somnath PaulDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Qiwen DongMolecular and Cellular Biology Program, Stony Brook University , Stony Brook, New York, USA.
Orchi AnannyaDepartment of Physiology and Biophysics, Molecular and Cellular Biology Program, Stony Brook University , Stony Brook, New York, USA.
Darby G OldenburgGundersen Medical Foundation, Gunderson Health System , La Crosse, Wisconsin, USA.
J Craig ForrestDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences , Little Rock, Arkansas, USA.
Kevin M McBrideDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center , Houston, Texas, USA.ORCID 0000-0001-9646-152X
Laurie T KrugHIV and AIDS Malignancy Branch, National Cancer Institute , Bethesda, Maryland, USA.ORCID 0000-0002-9648-522X
National Cancer Institute · USStony Brook University · USThe University of Texas MD Anderson Cancer Center · USGundersen Health System · USUniversity of Arkansas for Medical Sciences · US

Funding

Gammaherpesvirus interactions with host tumor suppressor p53R01CA167065 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI James Craig Forrest · 2014 to 2026
$3.8M
Uracil DNA Glycosylases in Gammaherpesvirus Pathogenesis and B Cell DevelopmentR01AI125397 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MCBRIDE, KEVIN MICHAEL · 2016 to 2020
$2.4M
Intramural NIH HHS IntramuralNCI NIH HHS R01 CA167065NCI NIH HHS R01CA167065NIAID NIH HHS R01 AI125397NIH HHS R01AI12539NIH HHS R21Al111129
6 · The paper itself

Abstract

Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied to date has demonstrated conservation of the enzymatic function to excise uracil residues from DNA. We previously reported that a murine gammaherpesvirus (MHV68) with a stop codon in

Indexed as

GammaherpesvirinaeRhadinovirusAnimalsDNA-Directed DNA PolymeraseDNA ReplicationDNA, ViralMammalsMiceUracilUracil-DNA GlycosidaseVirus ReplicationDNA-Directed DNA PolymeraseDNA, ViralUracilUracil-DNA Glycosidasegammaherpesviruslytic replicationuracil-DNA glycosylaseviral DNA polymeraseviral DNA polymerase processivity factorviral replication compartmentvirus-host interactions

Identifiers

PMID37747202
PMCPMC10597349
OpenAlexW4387001911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.