ArticleJournal of diabetes2024
Association of lactate dehydrogenase and diabetic retinopathy in US adults with diabetes mellitus.
Article in Journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 14 citations in OpenAlex.
- Association of vitamin D3 and diabetic retinopathy in US adults: A cross-sectional study.Medicine · 2026Article
- Vasant Kusumakar Rasa reduces neovascularisation, oxidative stress, inflammation and improves retinal function in diabetic rats.Journal of molecular histology · 2026Article
- An LLM-assisted framework for accelerated and verifiable clinical hypothesis testing from electronic health records.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetic regulation by HDAC11-driven STAT3 activation promotes pro-inflammatory cytokine production and endothelial dysfunction upon bacterial infection in diabetes.Cell communication and signaling : CCS · 2026Article
- Assessment of TG/HDL-C and METS-IR as markers for diabetic retinopathy risk and severity in type 2 diabetes.Frontiers in medicine · 2026Article
- Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy.Journal of clinical medicine · 2025Article
- The predictive value of family income to poverty ratio and diabetic retinopathy in adults aged 20 years and above in the United States: a cross-sectional study based on NHANES 1999-2020.BMC public health · 2025Article
- Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics.Cardiovascular research · 2025Article
- Tear lactate improves the evaluation of proliferative diabetic retinopathy in type-2 diabetes patients.Molecular biomedicine · 2025Article
- Glyceraldehyde-3-phosphate dehydrogenase/1,3-bisphosphoglycerate-NADH as key determinants in controlling human retinal endothelial cellular functions: Insights from glycolytic screening.The Journal of biological chemistry · 2025Article
- Relationship between serum LDH levels and diabetic peripheral neuropathy in type 2 diabetic patients.Frontiers in endocrinology · 2025Article
- Positive association between serum lactate dehydrogenase levels and blood pressure: evidence from NHANES 2015-2016.Frontiers in cardiovascular medicine · 2025Article
- Association of lactate dehydrogenase and diabetic retinopathy in US adults with diabetes mellitus.Journal of diabetes · 2024Article
- Factors related to type 2 diabetic retinopathy and their clinical application value.Frontiers in endocrinology · 2024Article
- High myopia is protective against diabetic retinopathy in the participants of the National Health and Nutrition Examination Survey.BMC ophthalmology · 2023Article
- U-Shaped Relationship Between Serum Lactate Dehydrogenase With Diabetic Lower Extremity Ulcers Among Diabetic Patients Aged ≥ 40 Years in NHANES.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of our investigation is to evaluate the level of relationship between lactate dehydrogenase (LDH) and the occurrence of diabetic retinopathy (DR) in adults with diabetes mellitus (DM).
methodsThe investigation involved an analysis of five sectional data cycles acquired from the National Health and Nutrition Examination Survey from 2009 to 2018. The present study involved the selection of DM samples from a complex multistage probability sample. These samples were subsequently classified into two distinct groups, namely the No DR (NDR) and DR groups. The present study comprehensively investigated the biological and social risk factors associated with DR. The biological factors examined in this investigation included blood pressure, blood routine, hemoglobin A1c, blood glucose, and comorbidities. The social dimensions encompass education and sex.
resultsAfter considering all factors, multivariate regression models indicated a significant relationship between DR and increased LDH (adjusted odds ratio = 1.007, 95% confidence interval: 1.003-1.011). The subgroup analysis revealed that the effect size of LDH on the existence of DR in the subgroups remained consistent, as indicated by all p values greater than .05. A statistically significant relationship was identified between elevated LDH levels > 134 U/L and a raised risk of DR in people with DM.
conclusionLDH concentrations were connected with an increased prevalence of DR in participants with DM. Our study highlights that patients with LDH > 134 U/L are distinguishably related to DM complicated by DR. DR is more common in diabetic individuals with coronary heart disease.
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