SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Risk, protective, and biomarkers of dementia in Indigenous peoples: A systematic review.
Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Risk, protective, and biomarkers of dementia in Indigenous peoples: A systematic review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Detection of cognitive impairment, dementia and associated risk factors among Aboriginal and Torres Strait Islander peoples: Retrospective baseline audit results from a stepped-wedge cluster-randomised controlled trial.Australasian journal on ageing · 2025Trial
- Incidence of dementia and mild cognitive impairment in two Indigenous Bolivian cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Incidence and risk factors for AD/ADRD among American Indian and Alaska Native US Veterans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Numeracy, literacy, and formal education as mechanisms of inequities in late-life cognitive performance between Indigenous-speaking and non-Indigenous-speaking older Mexican adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The incidence of dementia in populations around the globe.Current opinion in psychiatry · 2026Review
- Advancing brain health equity with Indigenous peoples: A critical imperative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- A qualitative study to create a framework of Métis understandings of brain health promotion and dementia prevention in Alberta, Canada.Frontiers in dementia · 2026Article
- Psychometric properties of the Rowland Universal Dementia Assessment Scale - Peruvian Version among Indigenous Amazonian communities.NPJ dementia · 2026Article
- Older Aboriginal and Torres Strait Islander populations living with dementia: State and territory scenario-based projections into the future.Australasian journal on ageing · 2025Article
- A Prototype Rapid Tool to Enhance Detection of Dementia for Aboriginal and Torres Strait Islander Peoples in Primary Care.International journal of geriatric psychiatry · 2025Article
- Culturally safe and ethical biomarker and genomic research with Indigenous peoples-a scoping review.BMC global and public health · 2024Article
- Dementia diagnostic and treatment services in the Western Pacific: challenges, preparedness and opportunities in the face of amyloid-targeting therapies.The Lancet regional health. Western Pacific · 2024Review
- Epidemiology and prevalence of dementia and Alzheimer's disease in American Indians: Data from the Strong Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- A nomogram based on neuron-specific enolase and substantia nigra hyperechogenicity for identifying cognitive impairment in Parkinson's disease.Quantitative imaging in medicine and surgery · 2024Article
- Prevalence and risk factors for Alzheimer's disease and related dementias in Ghana: Evidence from a cross-sectional population-based study.Cogent public health · 2024Article
- Considerations for disclosing Alzheimer's disease risk and biomarker results in a Pueblo community in Southwest United States.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Willing, but unequally: Indigenous identity influences participation in Alzheimer's disease biomarker research in Chile.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Bilingualism was not associated with a cognitive advantage among older Mexican adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
introductionDementia is an emergent health priority for Indigenous peoples worldwide, yet little is known about disease drivers and protective factors.
methodsDatabase searches were conducted in March 2022 to identify original publications on risk, protective, genetic, neuroradiological, and biological factors related to dementia and cognitive impairment involving Indigenous peoples.
resultsModifiable risk factors featured across multiple studies include childhood adversity, hearing loss, low education attainment, unskilled work history, stroke, head injury, epilepsy, diabetes, hypertension, hyperlipidemia, depression, low BMI, poor mobility, and continence issues. Non-modifiable risk factors included increasing age, sex, and genetic polymorphisms. Education, ex-smoking, physical and social activity, and engagement with cultural or religious practices were highlighted as potential protective factors. There is a paucity of research on dementia biomarkers involving Indigenous peoples. DISCUSSION: Greater understanding of modifiable factors and biomarkers of dementia can assist in strength-based models to promote healthy ageing and cognition for Indigenous peoples.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.