Evidence map›Paper›PMID 37746650›Full record

ArticleWorld journal of gastrointestinal oncology2023

Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma.

Hao Sun, Jie Ma, Jian Lu, Zhi-Hong Yao, Hai-Liang Ran, Hai Zhou, Zhong-Qin Yuan, Yun-Chao Huang, Yuan-Yuan Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hao SunNHC Key Laboratory of Drug Addiction Medicine, School of Public Health, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Jie MaThe Third Affiliated Hospital, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Jian LuThe Third Affiliated Hospital, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Zhi-Hong YaoThe Third Affiliated Hospital, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Hai-Liang RanNHC Key Laboratory of Drug Addiction Medicine, School of Public Health, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Hai ZhouThe Third Affiliated Hospital, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Zhong-Qin YuanThe Third Affiliated Hospital, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Yun-Chao HuangThe Third Affiliated Hospital, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Yuan-Yuan XiaoNHC Key Laboratory of Drug Addiction Medicine, School of Public Health, Kunming Medical University, Kunming 650500, Yunnan Province, China. 33225647@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFibrinogen-to-albumin ratio (FAR) has been found to be of prognostic significance for several types of malignant tumors. However, less is known about the association between FAR and survival outcomes in hepatocellular carcinoma (HCC) patients.

aimTo explore the association between FAR and prognosis and survival in patients with HCC.

methodsA total of 366 histologically confirmed HCC patients diagnosed between 2013 and 2018 in a provincial cancer hospital in southwestern China were retrospectively selected. Relevant data were extracted from the hospital information system. The optimal cutoff for baseline serum FAR measured upon disease diagnosis was established using the receiver operating characteristic (ROC) curve. Univariate and multivariate Cox proportional hazards models were used to determine the crude and adjusted associations between FAR and the overall survival (OS) of the HCC patients while controlling for various covariates. The restricted cubic spline (RCS) was applied to estimate the dose-response trend in the FAR-OS association.

resultsThe optimal cutoff value for baseline FAR determined by the ROC was 0.081. Multivariate Cox proportional hazards model revealed that a lower baseline serum FAR level was associated with an adjusted hazard ratio of 2.43 (95% confidence interval: 1.87-3.15) in the OS of HCC patients, with identifiable dose-response trend in the RCS. Subgroup analysis showed that this FAR-OS association was more prominent in HCC patients with a lower baseline serum aspartate aminotransferase or carbohydrate antigen 125 level.

conclusionSerum FAR is a prominent prognostic indicator for HCC. Intervention measures aimed at reducing FAR might result in survival benefit for HCC patients.

Indexed as

Cox proportional hazards modelFibrinogen-to-albumin ratioHepatocellular carcinomaOverall survivalSurvival analysis

Identifiers

PMID37746650
PMCPMC10514720

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.