ArticleFrontiers in fungal biology2022
Genome mining as a biotechnological tool for the discovery of novel biosynthetic genes in lichens.
Article in Frontiers in fungal biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Genome-guided discovery and computational prioritization of next generation drug development fromFrontiers in microbiology · 2026Article
- Paired-omics-based exploration and characterization of biosynthetic diversity in lichenized fungi.Microbial genomics · 2025Article
- A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont.Environmental microbiology · 2025Article
- Bioinformatic exploration of RiPP biosynthetic gene clusters in lichens.Fungal biology and biotechnology · 2025Article
- Lichens and Health-Trends and Perspectives for the Study of Biodiversity in the Antarctic Ecosystem.Journal of fungi (Basel, Switzerland) · 2025Review
- Microbial occurrence and symbiont detection in a global sample of lichen metagenomes.PLoS biology · 2024Article
- Mining Biosynthetic Gene Clusters ofMicroorganisms · 2024Article
- Linking Lichen Metabolites to Genes: Emerging Concepts and Lessons from Molecular Biology and Metagenomics.Journal of fungi (Basel, Switzerland) · 2023Review
- Article
- Discovery and excavation of lichen bioactive natural products.Frontiers in microbiology · 2023Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural products (NPs) and their derivatives are a major contributor to modern medicine. Historically, microorganisms such as bacteria and fungi have been instrumental in generating drugs and lead compounds because of the ease of culturing and genetically manipulating them. However, the ever-increasing demand for novel drugs highlights the need to bioprospect previously unexplored taxa for their biosynthetic potential. Next-generation sequencing technologies have expanded the range of organisms that can be explored for their biosynthetic content, as these technologies can provide a glimpse of an organism's entire biosynthetic landscape, without the need for cultivation. The entirety of biosynthetic genes can be compared to the genes of known function to identify the gene clusters potentially coding for novel products. In this study, we mine the genomes of nine lichen-forming fungal species of the genus
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