Evidence map›Paper›PMID 37746156›Full record

ArticleFrontiers in neuroscience2023

Transcutaneous auricular Vagus Nerve Stimulation and Median Nerve Stimulation reduce acute stress in young healthy adults: a single-blind sham-controlled crossover study.

Jesus Antonio Sanchez-Perez, Asim H Gazi, Farhan N Rahman, Alexis Seith, Georgia Saks, Srirakshaa Sundararaj, Rachel Erbrick, Anna B Harrison, Christopher J Nichols, Mihir Modak and 4 more

Abstract read
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Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Neuromodulation in the intensive care unit.Intensive care medicine · 2024
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jesus Antonio Sanchez-PerezSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Asim H GaziSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Farhan N RahmanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Alexis SeithWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Georgia SaksWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Srirakshaa SundararajCollege of Sciences, Georgia Institute of Technology, Atlanta, GA, United States.
Rachel ErbrickSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Anna B HarrisonSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Christopher J NicholsSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.
Mihir ModakDepartment of Bioengineering, University of Maryland, College Park, MD, United States.
Yekanth R ChalumuriDepartment of Mechanical Engineering, University of Maryland, College Park, MD, United States.
Teresa K SnowSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, United States.
Jin-Oh HahnDepartment of Mechanical Engineering, University of Maryland, College Park, MD, United States.
Omer T InanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress is a major determinant of health and wellbeing. Conventional stress management approaches do not account for the daily-living acute changes in stress that affect quality of life. The combination of physiological monitoring and non-invasive Peripheral Nerve Stimulation (PNS) represents a promising technological approach to quantify stress-induced physiological manifestations and reduce stress during everyday life. This study aimed to evaluate the effectiveness of three well-established transcutaneous PNS modalities in reducing physiological manifestations of stress compared to a sham: auricular and cervical Vagus Nerve Stimulation (taVNS and tcVNS), and Median Nerve Stimulation (tMNS). Using a single-blind sham-controlled crossover study with four visits, we compared the stress mitigation effectiveness of taVNS, tcVNS, and tMNS, quantified through physiological markers derived from five physiological signals peripherally measured on 19 young healthy volunteers. Participants underwent three acute mental and physiological stressors while receiving stimulation. Blinding effectiveness was assessed via subjective survey. taVNS and tMNS relative to sham resulted in significant changes that suggest a reduction in sympathetic outflow following the acute stressors: Left Ventricular Ejection Time Index (LVETI) shortening (tMNS:

Indexed as

Median Nerve Stimulationmultimodal sensingnon-invasivephysiological signalsstressVagus Nerve Stimulation

Identifiers

PMID37746156
PMCPMC10512834

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.