Evidence map›Paper›PMID 37745940›Full record

ArticleAdvanced functional materials2021

Oxygen-Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors.

Thibault Colombani, Loek J Eggermont, Stephen M Hatfield, Zachary J Rogers, Mahboobeh Rezaeeyazdi, Adnan Memic, Michail V Sitkovsky, Sidi A Bencherif

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 40 citations in OpenAlex.

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  18. Designing Silk-Based Cryogels for Biomedical Applications.Biomimetics (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Thibault ColombaniDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Loek J EggermontDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Stephen M HatfieldNew England Inflammation and Tissue Protection Institute, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.
Zachary J RogersDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Mahboobeh RezaeeyazdiDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Adnan MemicCenter of Nanotechnology, King Abdulaziz University, Jeddah, Makkah 21589, Saudi Arabia.
Michail V SitkovskyNew England Inflammation and Tissue Protection Institute, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.
Sidi A BencherifDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Northeastern University · USKing Abdulaziz University · SAUniversité de Technologie de Compiègne · FR

Funding

Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapyR01EB027705 · NIBIB · NORTHEASTERN UNIVERSITY · PI HATFIELD, STEPHEN MATTHEW · 2021 to 2024
$1.9M
NIBIB NIH HHS R01 EB027705
6 · The paper itself

Abstract

Solid tumors are protected from antitumor immune responses due to their hypoxic microenvironments. Weakening hypoxia-driven immunosuppression by hyperoxic breathing of 60% oxygen has shown to be effective in unleashing antitumor immune cells against solid tumors. However, efficacy of systemic oxygenation is limited against solid tumors outside of lungs and has been associated with unwanted side effects. As a result, it is essential to develop targeted oxygenation alternatives to weaken tumor hypoxia as novel approaches to restore immune responses against cancer. Herein, we report on injectable oxygen-generating cryogels (O

Indexed as

CancerCryogelsHypoxiaOxygenationT cell-mediated Antitumor Activity

Identifiers

PMID37745940
PMCPMC10516343
OpenAlexW3176042847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.