Evidence map›Paper›PMID 37745893›Full record

ArticleCerebral circulation - cognition and behavior2023

Subjective vs informant-reported cognitive complaints have differential clinical significance in covert cerebral small vessel disease.

Anne Arola, Hanna M Laakso, Heidi Heinonen, Johanna Pitkänen, Matti Ahlström, Juha Lempiäinen, Teemu Paajanen, Jussi Virkkala, Juha Koikkalainen, Jyrki Lötjönen and 3 more

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Article in Cerebral circulation - cognition and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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13 authors.

Anne ArolaDivision of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Hanna M LaaksoDivision of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Heidi HeinonenDivision of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Johanna PitkänenDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Matti AhlströmDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Juha LempiäinenDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Teemu PaajanenWork ability and working careers, Finnish Institute of Occupational Health, Helsinki, Finland.
Jussi VirkkalaDepartment of Neurophysiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juha KoikkalainenCombinostics Ltd, Tampere, Finland.
Jyrki LötjönenCombinostics Ltd, Tampere, Finland.
Antti KorvenojaMedical Imaging Center, Radiology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Susanna MelkasDepartment of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Hanna JokinenDivision of Neuropsychology, HUS Neurocenter, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Subjective cognitive complaints are common in patients with cerebral small vessel disease (cSVD), yet their relationship with informant evaluations, objective cognitive functions and severity of brain changes are poorly understood. We studied the associations of subjective and informant reports with findings from comprehensive neuropsychological assessment and brain MRI. Method: In the Helsinki SVD Study, 152 older adults with varying degrees of white matter hyperintensities (WMH) but without stroke or dementia were classified as having normal cognition or mild cognitive impairment (MCI) based on neuropsychological criteria. The measures also included continuous domain scores for memory and executive functions. Cognitive complaints were evaluated with the subjective and informant versions of the Prospective and Retrospective Memory Questionnaire (PRMQ) and Dysexecutive Questionnaire (DEX); functional abilities with the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL); and depressive symptoms with the Geriatric Depression Scale (GDS-15). Results: Subjective cognitive complaints correlated significantly with informant reports ( Conclusions: Neither subjective nor informant-reported cognitive complaints associated with objective cognitive performance. Informant-evaluations were related to functional impairment and more severe WMH, whereas subjective complaints only associated with mild depressive symptoms. These findings suggest that awareness of cognitive impairment may be limited in early-stage cSVD and highlight the value of informant assessments in the identification of patients with functional impairment.

Indexed as

Awareness of cognitive impairmentCerebral small vessel diseaseCognitionMild cognitive impairmentSubjective cognitive complaintsWhite matter hyperintensities

Identifiers

PMID37745893
PMCPMC10514088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.