ArticleFrontiers in endocrinology2023
Sequential embryo transfer versus double cleavage-stage embryo or double blastocyst transfer in patients with recurrent implantation failure with frozen-thawed embryo transfer cycles: a cohort study.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sequential embryo transfer efficacy in enhancing pregnancy outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Outcomes of Single Blastocyst Transfer Versus Double Cleavage-Stage Embryo Transfer in Young Women with Recurrent Implantation Failure: A Secondary Analysis of a Multicenter Randomized Trial.Journal of clinical medicine · 2026Article
- Sequential blastocyst transfer improved pregnancy outcomes in patients undergoing frozen-thawed embryo transfer cycles: who will be the ultimate beneficiary.Frontiers in endocrinology · 2026Article
- Clinical pregnancy, live birth, and twin pregnancy outcomes of nine frozen-thawed embryo transfer strategies across female age groups: a real-world cohort study.Frontiers in endocrinology · 2026Article
- The Impact of Cleavage and Blastocyst Stage Sequential Transfer on Clinical Pregnancy Outcomes of Frozen Embryo Transfer in Patients with Multiple Transplant Failures: A Retrospective Cohort Study.International journal of women's health · 2026Article
- Sequential Transfer of Blastocysts on Day 5 and Day 6 in Patients with Repeated Implantation Failure in Frozen Embryo Transfer Cycle.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Live birth rate and perinatal outcomes following sequential embryo transfer in women with recurrent implantation failure undergoing frozen-thawed embryo transfer cycles.BMC pregnancy and childbirth · 2025Article
- Comparison of double blastocyst transfer versus sequential transfer on pregnancy outcomes in individuals with frozen embryo transfer and a history of recurrent implantation failure: An RCT.International journal of reproductive biomedicine · 2025Article
- Anomaly Detection in Embryo Development and Morphology Using Medical Computer Vision-Aided Swin Transformer with Boosted Dipper-Throated Optimization Algorithm.Bioengineering (Basel, Switzerland) · 2024Article
- Effect of sequential cleavage and blastocyst embryo transfer compared to single cleavage stage embryo transfer on assisted reproductive technology outcome: An RCT.International journal of reproductive biomedicine · 2024Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recurrent implantation failure (RIF) is more common among patients receiving assisted reproductive treatment. Many efforts have been made to increase the incidence of clinical pregnancy among patients with RIF. The effect of the sequential transfer procedure, a two-step interval transfer of a cleavage-stage embryo followed by a blastocyst in one transfer cycle, on the clinical outcomes of RIF patients remains controversial. Methods: In total, 1774 frozen-thawed embryo transfer (FET) cycles in RIF patients were included. Of these cycles, 302 were sequential embryo transfer (ET) cycles, 979 were double day 3 cleavage-stage ET cycles, and 493 were double blastocyst ET cycles. The primary outcomes were the rates of implantation, clinical pregnancy and multiple pregnancy, and the secondary outcomes were the rates of hCG positive, early miscarriage and ectopic pregnancy. Results: The implantation, hCG positive, and clinical pregnancy rates in the sequential ET group (32.1%, 58.9%, 50.7%) were significantly higher than those in the day 3 cleavage-stage ET group (24.9%, 46.5%, 40.4%) and were similar to those in the blastocyst transfer group (30.1%, 56.4%, 47.1%). The early miscarriage rate in the blastocyst transfer group was significantly higher than that in the cleavage-stage ET group (17.2% vs. 8.1%, Conclusions: Sequential embryo transfer in FET cycles could improve the clinical outcomes of patients with RIF.
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