Evidence map›Paper›PMID 37745614›Full record

ArticlebioRxiv : the preprint server for biology2023

Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease.

Joshua S Weinstock, Maya M Arce, Jacob W Freimer, Mineto Ota, Alexander Marson, Alexis Battle, Jonathan K Pritchard

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Joshua S WeinstockDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Maya M ArceGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA.
Jacob W FreimerDepartment of Genetics, Stanford University, Stanford, CA.
Mineto OtaDepartment of Genetics, Stanford University, Stanford, CA.
Alexander MarsonGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA.
Alexis BattleDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD.
Jonathan K PritchardDepartment of Genetics, Stanford University, Stanford, CA.
Gladstone Institutes · USJohns Hopkins University · USStanford University · US

Funding

Utilizing Technology and AI Approaches to Facilitate Independence andResilience in Older AdultsP30AG073104 · NIA · JOHNS HOPKINS UNIVERSITY · PI Alexis Battle · 2021 to 2026
$31.2M
Integration of genetic association mapping and functional data to elucidate genetic mechanisms of diseaseR01HG008140 · NHGRI · STANFORD UNIVERSITY · PI JONATHAN K PRITCHARD · 2016 to 2026
$7.3M
Modeling the dynamicimpact of rare and common genetic variation on gene expression anddiseaseR35GM139580 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BATTLE, ALEXIS · 2021 to 2025
$3.1M
NHGRI NIH HHS R01 HG008140NIA NIH HHS P30 AG073104NIGMS NIH HHS R35 GM139580
6 · The paper itself

Abstract

The effects of genetic variation on complex traits act mainly through changes in gene regulation. Although many genetic variants have been linked to target genes in

Identifiers

PMID37745614
PMCPMC10516010
OpenAlexW4386811449

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.