Evidence map›Paper›PMID 37745540›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Association between Haloperidol use and Risk of Rheumatoid Arthritis.

Vidya L Ambati, Tammy H Cummings, Praveen Yerramothu, Joseph Nguyen, S Scott Sutton, Brian C Werner, Joseph Magagnoli

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vidya L AmbatiCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, Virginia.
Tammy H CummingsDorn Research Institute, Columbia VA Health Care System, Columbia, South Carolina.
Praveen YerramothuCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, Virginia.
Joseph NguyenCenter for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, Virginia.
S Scott SuttonDorn Research Institute, Columbia VA Health Care System, Columbia, South Carolina.
Brian C WernerDepartment of Orthopaedics, University of Virginia School of Medicine, Charlottesville, Virginia.
Joseph MagagnoliDorn Research Institute, Columbia VA Health Care System, Columbia, South Carolina.
University of Virginia · USUniversity of South Carolina · US

Funding

Non-canonical inflammasome in activation in RPE degenerationR01EY029799 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2019 to 2022
$2.7M
Knowledge discovery and machine learning to elucidate the mechanisms of HIV activity and interaction with substance use disorderR01DA054992 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SAFRO, ILYA, SHTUTMAN, MICHAEL · 2021 to 2025
$2.1M
NEI NIH HHS R01 EY029799NIDA NIH HHS R01 DA054992
6 · The paper itself

Abstract

Haloperidol is an anti-psychotic used for the treatment of schizophrenia or Tourette disorder. Here we report, by studying three large administrative health insurance databases, that haloperidol use is associated with a reduced risk of developing rheumatoid arthritis. A meta-analysis revealed a 31% reduced hazard of incident rheumatoid arthritis among individuals with schizophrenia or Tourette disorder treated with haloperidol compared to those treated with other anti-psychotic drugs. These findings suggest a potential benefit of haloperidol in rheumatoid arthritis and provide a rationale for randomized controlled trials to provide causal insights.

Identifiers

PMID37745540
PMCPMC10516091
OpenAlexW4386646761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.