Evidence map›Paper›PMID 37745534›Full record

ArticlebioRxiv : the preprint server for biology2023

Protein phosphatase 1 regulates core PCP signaling.

Song Song, Bomsoo Cho, Alexis T Weiner, Silas Boye Nissen, Irene Ojeda Naharros, Pablo Sanchez Bosch, Kaye Suyama, Yanhui Hu, Li He, Tanya Svinkina and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Song SongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bomsoo ChoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alexis T WeinerDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Silas Boye NissenDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Irene Ojeda NaharrosDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA 94143-3120, USA.
Pablo Sanchez BoschDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Kaye SuyamaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Li HeDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Tanya SvinkinaBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Namrata D UdeshiBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA 02142.
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Jeffrey D AxelrodDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USBroad Institute · USAllscripts (United States) · USHarvard University · USHoward Hughes Medical Institute · USUniversity of California, San Francisco · USUniversity of Copenhagen · DKUniversity of Science and Technology of China · CN

Funding

Mapping protein communication between organs in homeostasis and diseaseR01DK121409 · NIDDK · HARVARD MEDICAL SCHOOL · PI CARR, STEVEN A, MCMAHON, ANDREW P. · 2018 to 2022
$8.3M
Planar cell polarity mechanisms and systems architectureR35GM131914 · NIGMS · STANFORD UNIVERSITY · PI Jeffrey D. Axelrod · 2019 to 2026
$7.4M
NIDDK NIH HHS R01 DK121409NIGMS NIH HHS R35 GM131914
6 · The paper itself

Abstract

PCP signaling polarizes epithelial cells within the plane of an epithelium. Core PCP signaling components adopt asymmetric subcellular localizations within cells to both polarize and coordinate polarity between cells. Achieving subcellular asymmetry requires additional effectors, including some mediating post-translational modifications of core components. Identification of such proteins is challenging due to pleiotropy. We used mass spectrometry-based proximity labeling proteomics to identify such regulators in the

Indexed as

APEX proximity labelingPlanar cell polarityPp1-87B protein phosphataseVan gogh

Identifiers

PMID37745534
PMCPMC10515792
OpenAlexW4386699956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.