Evidence map›Paper›PMID 37745519›Full record

ArticlebioRxiv : the preprint server for biology2023

Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.

Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Tom Warner, John Hardy, Patrick A Lewis, Jennifer Pocock, Mark R Cookson and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Iqra NazishReta Lila Weston Institute of Neurological Studies and Department of movement neuroscience, UCL Queen Square Institute of Neurology, London WC1N 1PJ.
Adamantios MamaisCenter for Translational Research in Neurodegenerative Disease, Department of Neurology, University of Florida, Gainesville, FL, USA.
Anna MallachDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, WC1N 1PJ, UK.
Conceicao BettencourtDepartment of Neurodegenerative diseases, UCL Queen Square Institute of Neurology.
Alice KaganovichCell Biology and Gene Expression section, NIA, Maryland, USA.
Tom WarnerReta Lila Weston Institute of Neurological Studies and Department of movement neuroscience, UCL Queen Square Institute of Neurology, London WC1N 1PJ.
John HardyDepartment of Neurodegenerative diseases, UCL Queen Square Institute of Neurology.
Patrick A LewisDepartment of Neurodegenerative diseases, UCL Queen Square Institute of Neurology.
Jennifer PocockDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, WC1N 1PJ, UK.
Mark R CooksonCell Biology and Gene Expression section, NIA, Maryland, USA.
Rina BandopadhyayReta Lila Weston Institute of Neurological Studies and Department of movement neuroscience, UCL Queen Square Institute of Neurology, London WC1N 1PJ.
National Hospital for Neurology and Neurosurgery · GBQueen Mary University of London · GBUniversity of Florida · USUniversity of London · GB

Funding

PATHOLOGIC LRRK2 SIGNALING IN FAMILIAL AND IDIOPATHIC PARKINSON'S DISEASER01NS110188 · NINDS · UNIVERSITY OF FLORIDA · PI LAVOIE, MATTHEW J · 2018 to 2022
$2.3M
Dysregulation of iron homeostasis by mutant LRRK2 in human neuronsR21AG077269 · NIA · UNIVERSITY OF FLORIDA · PI MAMAIS, ADAMANTIOS · 2023 to 2024
$419k
NIA NIH HHS R21 AG077269NINDS NIH HHS R01 NS110188
6 · The paper itself

Abstract

Introduction: Mutations in the Leucine Rich Repeat Kinase 2 ( Methods: Here, we investigated the effects of zymosan, a TLR2 agonist and the potent and specific LRRK2 kinase inhibitor MLi-2 on gene expression in microglia from Results: We observed both overlapping and distinct zymosan and MLi-2 mediated gene expression profiles in microglia. At least two candidate Genome-Wide Association (GWAS) hits for PD, CathepsinB ( Discussion: Overall, these results suggest that microglial LRRK2 may contribute to PD pathogenesis through altered inflammatory pathways. Our findings should encourage future investigations of these putative avenues in the context of PD pathogenesis.

Indexed as

G2019S knock-inLRRK2MLi.2RNA-SeqTLR2zymosan

Identifiers

PMID37745519
PMCPMC10515904
OpenAlexW4386727493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.