Evidence map›Paper›PMID 37745474›Full record

ArticlebioRxiv : the preprint server for biology2023

Reentrant DNA shells tune polyphosphate condensate size.

Ravi Chawla, Jenna K A Tom, Tumara Boyd, Danielle A Grotjahn, Donghyun Park, Ashok A Deniz, Lisa R Racki

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ravi ChawlaDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Jenna K A TomDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Tumara BoydDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Danielle A GrotjahnDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Donghyun ParkDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Ashok A DenizDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Lisa R RackiDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Scripps Research Institute · US

Funding

Using phage to interrogate bacterial heterochromatinDP2GM140918 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI RACKI, LISA R · 2020 to 2020
$2.7M
Biophysics of Protein Disorder and Complexity, Single Molecules to MesoscalesR35GM130375 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DENIZ, ASHOK A · 2019 to 2023
$2.4M
High-speed direct detector for cryo electron microscopyS10OD032467 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI LANDER, GABRIEL C · 2022 to 2022
$600k
NIGMS NIH HHS DP2 GM140918NIGMS NIH HHS R35 GM130375NIH HHS S10 OD032467
6 · The paper itself

Abstract

The ancient, inorganic biopolymer polyphosphate (polyP) occurs in all three domains of life and affects myriad cellular processes. An intriguing feature of polyP is its frequent proximity to chromatin, and in the case of many bacteria, its occurrence in the form of magnesium-enriched condensates embedded in the nucleoid, particularly in response to stress. The physical basis of the interaction between polyP and DNA, two fundamental anionic biopolymers, and the resulting effects on the organization of both the nucleoid and polyP condensates remain poorly understood. Given the essential role of magnesium ions in the coordination of polymeric phosphate species, we hypothesized that a minimal system of polyP, magnesium ions, and DNA (polyP-Mg

Identifiers

PMID37745474
PMCPMC10515899
OpenAlexW4386761274

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.