ArticlebioRxiv : the preprint server for biology2023
Early Deficits in Dentate Circuit and Behavioral Pattern Separation after Concussive Brain Injury.
Lucas Corrubia, Andrew Huang, Susan Nguyen, Michael W Shiflett, Mathew V Jones, Laura A Ewell, Vijayalakshmi Santhakumar
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors at 4 institutions in 1 country.
Lucas CorrubiaDepartment of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, New Jersey 07103.
Andrew HuangDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California 92521.
Susan NguyenDepartment of Molecular, Cell and Systems Biology, University of California Riverside, Riverside, California 92521.
Michael W ShiflettDepartment of Psychology, Rutgers University, Newark, NJ 07102.
Mathew V JonesDepartment of Neuroscience, University of Wisconsin, Madison, WI, 53705.
Laura A EwellDepartment of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697.
Vijayalakshmi SanthakumarDepartment of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, New Jersey 07103.
Rutgers, The State University of New Jersey · USUniversity of California, Riverside · USUniversity of California, Irvine · USUniversity of Wisconsin–Madison · US
Funding
Contribution of Innate Immune Receptors to Neurological Dysfunction After Traumatic Brain Injury: Mechanisms and Therapeutic ImplicationsR01NS097750 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SANTHAKUMAR, VIJAYALAKSHMI · 2016 to 2025
$4.0MPerisomatic Inhibitory Network Dysfunction in Neurological DiseaseR01NS069861 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI SANTHAKUMAR, VIJAYALAKSHMI · 2011 to 2022
$3.4MRole of TLR4 in Neuronal Excitability and Memory FunctionF31NS120620 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI NGUYEN, SUSAN T · 2021 to 2023
$118kRole of hippocampal adult-born granule cells in TBI-induced dentate gyrus circuit pathology and pattern separation deficitF31NS110220 · NINDS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CORRUBIA, LUCAS · 2019 to 2021
$116kCellular Mediators of Dentate Pattern Separation in EpilepsyF31NS131052 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HUANG, ANDREW · 2023 to 2024
$85kNINDS NIH HHS F31 NS110220NINDS NIH HHS F31 NS120620NINDS NIH HHS F31 NS131052NINDS NIH HHS R01 NS069861NINDS NIH HHS R01 NS097750
6 · The paper itselfAbstract
Traumatic brain injury leads to cellular and circuit changes in the dentate gyrus, a gateway to hippocampal information processing. Intrinsic granule cell firing properties and strong feedback inhibition in the dentate are proposed as critical to its ability to generate unique representation of similar inputs by a process known as pattern separation. Here we evaluate the impact of brain injury on cellular decorrelation of temporally patterned inputs in slices and behavioral discrimination of spatial locations
Indexed as
behaviordentate gyruselectrophysiologyfluid percussion injurygranule cellmemorytemporal pattern separationtraumatic brain injury
Identifiers
PMID37745454
PMCPMC10515770
OpenAlexW4382073064
What OpenQuestion holds
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LicenceCC BY-NC-ND
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