Evidence map›Paper›PMID 37745440›Full record

ArticlebioRxiv : the preprint server for biology2023

CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment.

Megan E Goeckel, Jihui Lee, Allison Levitas, Sarah Colijn, Geonyoung Mun, Zarek Burton, Bharadwaj Chintalapati, Ying Yin, Javier Abello, Amber Stratman

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Megan E GoeckelDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Jihui LeeDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Allison LevitasDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Sarah ColijnDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Geonyoung MunDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Zarek BurtonDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Bharadwaj ChintalapatiDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Ying YinDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Javier AbelloDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Amber StratmanDepartment of Cell Biology and Physiology, Washington University School of Medicine St. Louis, MO, 63110.
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterningR35GM137976 · NIGMS · WASHINGTON UNIVERSITY · PI STRATMAN, AMBER NICOLE · 2020 to 2024
$2.4M
NCATS NIH HHS UL1 TR002345NIGMS NIH HHS R35 GM137976
6 · The paper itself

Abstract

Endothelial cell (EC)-pericyte interactions are known to remodel in response to hemodynamic forces, yet there is a lack of mechanistic understanding of the signaling pathways that underlie these events. Here, we have identified a novel signaling network regulated by blood flow in ECs-the chemokine receptor, CXCR3, and one of its ligands, CXCL11-that delimits EC angiogenic potential and suppresses pericyte recruitment during development through regulation of

Indexed as

cardiovascular developmentchemokine signalingendothelial cellspericyte

Identifiers

PMID37745440
PMCPMC10516035
OpenAlexW4386811368

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.