Evidence map›Paper›PMID 37745432›Full record

ArticlebioRxiv : the preprint server for biology2023

Recurrent Viral Capture of Cellular Phosphodiesterases that Antagonize OAS-RNase L.

Stephen A Goldstein, Nels C Elde

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stephen A GoldsteinDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA Howard Hughes Medical Institute, 4000 Jones Bridge Rd, Chevy Chase, MD 20815, USA.
Nels C EldeDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA Howard Hughes Medical Institute, 4000 Jones Bridge Rd, Chevy Chase, MD 20815, USA.
Howard Hughes Medical Institute · US

Funding

Evolutionary innovations from host-microbe interactionsR35GM134936 · NIGMS · UNIVERSITY OF UTAH · PI ELDE, NELS C. · 2020 to 2024
$1.7M
Virus Evolution Through Horizontal Gene TransferF32AI152341 · NIAID · UNIVERSITY OF UTAH · PI GOLDSTEIN, STEPHEN · 2021 to 2023
$215k
NIAID NIH HHS F32 AI152341NIGMS NIH HHS R35 GM134936
6 · The paper itself

Abstract

Phosphodiesterases (PDEs) encoded by viruses are putatively acquired by horizontal transfer of cellular PDE ancestor genes. Viral PDEs inhibit the OAS-RNase L antiviral pathway, a key effector component of the innate immune response. Although the function of these proteins is well-characterized, the origins of these gene acquisitions is less clear. Phylogenetic analysis revealed at least five independent PDE acquisition events by ancestral viruses. We found evidence that PDE-encoding genes were horizontally transferred between coronavirus genera. Three clades of viruses within

Identifiers

PMID37745432
PMCPMC10515750
OpenAlexW4376618303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.