Evidence map›Paper›PMID 37745424›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.

Jeffrey A Tomalka, Anna Owings, Michelle Galeas-Pena, Carly G K Ziegler, Tanya O Robinson, Thomas G Wichman, Hannah Laird, Haley B Williams, Neha S Dhaliwal, Steven Everman and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Jeffrey A TomalkaDept. of Pathology and Laboratory Medicine. Emory University School of Medicine. Atlanta, GA, USA.
Anna OwingsDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Michelle Galeas-PenaDepartment of Medicine, Section of Gastroenterology and Hepatology, Tulane University School of Medicine. New Orleans, LA, USA.
Carly G K ZieglerProgram in Health Sciences & Technology, Harvard Medical School & MIT, Boston, MA, USA.
Tanya O RobinsonDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Thomas G WichmanDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Hannah LairdDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Haley B WilliamsDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Neha S DhaliwalDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Steven EvermanDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Yousaf ZafarDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Alex K ShalekProgram in Health Sciences & Technology, Harvard Medical School & MIT, Boston, MA, USA.
Bruce H HorwitzProgram in Immunology, Harvard Medical School, Boston, MA, USA.
Jose Ordovas-MontanesRagon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Sarah C GloverDepartment of Medicine, Section of Gastroenterology and Hepatology, Tulane University School of Medicine. New Orleans, LA, USA.
Yann GibertDept. of Cell and Molecular Biology; Cancer Center and Research Institute. University of Mississippi Medical Center. Jackson, MS, USA.
Jackson Memorial Hospital · USBroad Institute · USTulane University · USBoston Children's Hospital · USEmory University · USUniversity of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4M
Pilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI John E Hall · 2023 to 2026
$6.3M
Initiation of immune responses to SARS COV2 in the oral cavity and upper airwayR01DE031928 · NIDCR · UNIVERSITY OF MISSISSIPPI MED CTR · PI GILL DIAMOND, SARAH C GLOVER · 2022 to 2026
$3.8M
NIDCR NIH HHS R01 DE031928NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334NIGMS NIH HHS P30 GM149404NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Background: Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that Methods and findings: We performed a total fatty acid panel on plasma and bulk RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) collected from 10 infected and 10 uninfected patients. Univariate comparison of lipid metabolites revealed that lipid metabolites were increased in SARS-CoV-2 patients including the lipid mediators Arachidonic Acid (AA) and Eicosapentaenoic Acid (EPA). AA, EPA and the fatty acids Docosahexaenoic acid (DHA) and Docosapentaenoic acid (DPA), were positively correlated to WHO disease severity score. Transcriptomic analysis demonstrated that COVID-19 patients can be segregated based on WHO scores. Ontology, KEGG and Reactome analysis identified pathways enriched for genes related to innate immunity, interactions between lymphoid and nonlymphoid cells, interleukin signaling and, cell cycling pathways. Conclusions: Our study offers an association between nasopharynx mucosa eicosanoid genes expression, specific serum inflammatory lipids and, subsequent DNA damage pathways activation in PBMCs to severity of COVID-19 infection.

Indexed as

DNA damageeicosanoidsfatty acidlipidomicsRNAseqSARS-coV-2

Identifiers

PMID37745424
PMCPMC10516085
OpenAlexW4386764675

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.