Evidence map›Paper›PMID 37745421›Full record

ArticlebioRxiv : the preprint server for biology2023

Identification of Genetic and Genomic Influences on Progressive Ethanol Consumption in Diversity Outbred Mice.

M L Smith, Z Sergi, K M Mignogna, N E Rodriguez, Z Tatom, L MacLeod, K B Choi, V Philip, M F Miles

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

M L SmithDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
Z SergiDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
K M MignognaDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
N E RodriguezDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
Z TatomDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
L MacLeodDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
K B ChoiThe Jackson Laboratory, Bar Harbor, Maine, USA.
V PhilipThe Jackson Laboratory, Bar Harbor, Maine, USA.
M F MilesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA.
Virginia Commonwealth University · USJackson Laboratory · US

Funding

Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Amy Wolven Lasek · 2014 to 2026
$19.6M
Genetic and Transcriptomic Mechanisms of Progressive Ethanol Consumption in the Diversity Outbred MouseF31AA031189 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI TATOM, ZACHARY · 2023 to 2024
$85k
NIAAA NIH HHS F31 AA031189NIAAA NIH HHS P50 AA022537
6 · The paper itself

Abstract

Genetic factors play a significant role in the risk for development of alcohol use disorder (AUD). Using 3-bottle choice intermittent access ethanol (IEA), we have employed the Diversity Outbred (DO) mouse panel as a model of alcohol use disorder in a genetically diverse population. Through use of gene expression network analysis techniques, in combination with expression quantitative trait loci (eQTL) mapping, we have completed an extensive analysis of the influence of genetic background on gene expression changes in the prefrontal cortex (PFC). This approach revealed that, in DO mice, genes whose expression was significantly disrupted by intermittent ethanol in the PFC also tended to be those whose expression correlated to intake. This finding is in contrast to previous studies of both mice and nonhuman primates. Importantly, these analyses identified genes involved in myelination in the PFC as significantly disrupted by IEA, correlated to ethanol intake, and having significant eQTLs. Genes that code for canonical components of the myelin sheath, such as

Indexed as

Diversity OutbredeQTL mappingEthanolmouse geneticsnetwork analysisRNAseq

Identifiers

PMID37745421
PMCPMC10515943
OpenAlexW4386815489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.