Evidence map›Paper›PMID 37745414›Full record

ArticlebioRxiv : the preprint server for biology2023

PD-1 Mediated Regulation of Unique Activated CD8

Samantha M Borys, Shanelle P Reilly, Ian Magill, David Zemmour, Laurent Brossay

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Shanelle P ReillyORCID 0000-0001-9465-706X
Ian Magill

Funding

NK T Cell Interactions with NK Cells During Viral InfectionR01AI046709 · NIAID · BROWN UNIVERSITY · PI BROSSAY, LAURENT · 2001 to 2022
$8.0M
Immune response to MCMV infection in the salivary glandsR01AI173163 · NIAID · BROWN UNIVERSITY · PI Laurent Brossay · 2023 to 2026
$3.2M
PD-1 Mediated Regulation of Salivary Gland IntegrityF31DE032593 · NIDCR · BROWN UNIVERSITY · PI BORYS, SAMANTHA · 2023 to 2025
$136k
Investigating the role of salivary gland NK cells in controlling CMV infectionF31DE024360 · NIDCR · BROWN UNIVERSITY · PI ERICK, TIMOTHY KYLE · 2014 to 2015
$87k
NIAID NIH HHS R01 AI046709NIAID NIH HHS R01 AI173163NIDCR NIH HHS F31 DE024360NIDCR NIH HHS F31 DE032593
6 · The paper itself

Abstract

The increasing utilization of anti-PD-1 immune checkpoint blockade (ICB) has led to the emergence of immune-related adverse events (irAEs), including sicca syndrome. Interestingly, we found that the submandibular gland (SMG) of PD-1 deficient mice harbors a large population of CD8 Highlights: Elevated CD8

Identifiers

PMID37745414
PMCPMC10515922

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.