ArticlemedRxiv : the preprint server for health sciences2023
Genetic Variations in TrkB.T1 Isoform and Their Association with Somatic and Psychological Symptoms in Individuals with IBS.
H Hong, E Mocci, K Kamp, S Zhu, K C Cain, R L Burr, J Perry, M M Heitkemper, K R Weaver-Toedtman, S G Dorsey
Open access · greenAbstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors at 4 institutions in 1 country.
H HongDepartment of Biobehavioral Health Sciences, University of Pennsylvania School of Nursing.
E MocciDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing.
K KampDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing.
S ZhuDepartment of Organizational Systems and Adult Health, University of Maryland School of Nursing.
K C CainDepartment of Biostatistics, University of Washington School of Nursing.
R L BurrDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing.
J PerryDepartment of Medicine, University of Maryland School of Medicine.
M M HeitkemperDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing.
K R Weaver-ToedtmanDepartment of Biobehavioral Health and Nursing Science, University of South Carolina College of Nursing.
S G DorseyDepartment of Pain and Translational Symptom Science, University of Maryland School of Nursing.
University of Washington · USUniversity of Maryland, Baltimore · USUniversity of Pennsylvania · USUniversity of South Carolina · US
Funding
NURSING MANAGEMENT OF IBS--IMPROVING OUTCOMESR01NR004142 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN · 1996 to 2011
$5.5MNURSING STUDY OF GUT FUNCTION IN MENSTRUATING WOMENR01NR001094 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN · 1986 to 2013
$5.3MPartnership CoreP30NR004001 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN · 1994 to 2008
$3.7MOmics and Symptom Science Training ProgramT32NR016913 · NINR · UNIVERSITY OF WASHINGTON · PI CYNTHIA M DOUGHERTY, Margaret McLean Heitkemper · 2017 to 2026
$3.2MMicrobiome and Pain SupplementR01NR014479 · NINR · UNIVERSITY OF WASHINGTON · PI HEITKEMPER, MARGARET MCLEAN, SHULMAN, ROBERT J · 2014 to 2017
$1.8MA Comprehensive Self-Management Intervention for individuals with Inflammatory Bowel DiseaseK23NR020044 · NINR · UNIVERSITY OF WASHINGTON · PI KAMP, KENDRA JOY · 2022 to 2024
$430kNINR NIH HHS K23 NR020044NINR NIH HHS P30 NR004001NINR NIH HHS R01 NR001094NINR NIH HHS R01 NR004142NINR NIH HHS R01 NR014479NINR NIH HHS T32 NR016913
6 · The paper itselfAbstract
Irritable bowel syndrome (IBS), a disorder of gut-brain interaction, is often comorbid with somatic pain and psychological disorders. Dysregulated signaling of brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), has been implicated in somatic-psychological symptoms in individuals with IBS. Thus, we investigated the association of 10 single nucleotide polymorphisms (SNPs) in the regulatory 3' untranslated region (UTR) of
Indexed as
Irritable bowel syndromePsychological symptomsQuality of lifeSingle nucleotide polymorphismsSomatic symptoms
Identifiers
PMID37745409
PMCPMC10516087
OpenAlexW4386789356
What OpenQuestion holds
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