Evidence map›Paper›PMID 37745398›Full record

ArticlebioRxiv : the preprint server for biology2023

Killian S Hanlon, Ming Cheng, Demitri De La Cruz, Nikita Patel, Miguel C Santoscoy, Yi Gong, Carrie Ng, Diane M Nguyen, Josette Nammour, Sean W Clark and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Killian S HanlonDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Ming ChengDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Demitri De La CruzDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Nikita PatelDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Miguel C SantoscoyDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Yi GongDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Carrie NgDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Diane M NguyenDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Josette NammourDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Sean W ClarkSwanBio Therapeutics, Bala Cynwyd, PA.
Karen KozarskySwanBio Therapeutics, Bala Cynwyd, PA.
Casey A MaguireDepartment of Neurology, Massachusetts General Hospital, Boston, MA.
Harvard University · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Enhanced gene delivery for CNS and sensory disordersR01DC017117 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI MAGUIRE, CASEY A · 2019 to 2023
$1.8M
Aperio VERSA Digital Slide Scanner, eSlide Manager Database, and Advanced Image Analysis SoftwareS10OD023465 · OD · UNIVERSITY OF PENNSYLVANIA · PI DURHAM, AMY CLEVELAND · 2018 to 2018
$329k
NCI NIH HHS P30 CA016520NIDCD NIH HHS R01 DC017117NIH HHS S10 OD023465
6 · The paper itself

Abstract

Systemic administration of adeno-associated virus (AAV) vectors for spinal cord gene therapy has challenges including toxicity at high doses and pre-existing immunity that reduces efficacy. Intrathecal delivery of AAV vectors into the cerebral spinal fluid (CSF) can avoid many of the issues of systemic delivery, although achieving broad distribution of the vector and transgene expression throughout the spinal cord is challenging and vector entry to the periphery occurs, sometimes initiating hepatotoxicity. Here we performed two rounds of

Identifiers

PMID37745398
PMCPMC10515928
OpenAlexW4386744582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.