Evidence map›Paper›PMID 37745383›Full record

ArticlebioRxiv : the preprint server for biology2023

Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology.

Drake T Philip, Nigel M Goins, Nicholas J Catanzaro, Ichiro Misumi, Jason K Whitmire, Hannah M Atkins, Helen M Lazear

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Drake T PhilipDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.
Nigel M GoinsDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.
Nicholas J CatanzaroDepartment of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill.
Ichiro MisumiDepartment of Genetics, University of North Carolina at Chapel Hill.
Jason K WhitmireDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.
Hannah M AtkinsDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill.
Helen M LazearDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill.
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Molecular Biology of Viral Diseases Predoctoral Training GrantT32AI007419 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark T Heise, CARY A MOODY · 1993 to 2026
$4.7M
Regulation of CD8+ T cell responses to chronic virus infectionR01AI143894 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2019 to 2023
$2.5M
Antiviral and immunomodulatory effects of interferon lambda in the skinR01AI175708 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Helen Lazear · 2023 to 2026
$2.4M
The role of Interferon lambda signaling in flavivirus transmission and pathogenesis at the maternal-fetal interfaceR01AI139512 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2019 to 2023
$1.9M
Obesity associated viral pathogenesisR01AI138337 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WHITMIRE, JASON KYLE · 2018 to 2022
$1.9M
Murine Model of Human Hepatitis AR01AI131685 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEMON, STANLEY M., WHITMIRE, JASON KYLE · 2017 to 2021
$1.9M
Antiviral inhibition of ZCCHC14-TENT4 complex in hepatitis A virus infectionR21AI163606 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YOU, MISUMI, ICHIRO · 2021 to 2022
$428k
Temporal Functions of Interferon Lambda Signaling During Acute and Recurrent Herpes Simplex Virus Type 1 Skin InfectionF31AI167502 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PHILIP, DRAKE THOMAS · 2022 to 2023
$70k
NCI NIH HHS P30 CA016086NIAID NIH HHS F31 AI167502NIAID NIH HHS R01 AI131685NIAID NIH HHS R01 AI138337NIAID NIH HHS R01 AI139512NIAID NIH HHS R01 AI143894NIAID NIH HHS R01 AI175708NIAID NIH HHS R21 AI163606NIAID NIH HHS T32 AI007419NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Type III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought to define the skin-specific effects of IFN-λ against the highly prevalent human pathogen herpes simplex virus (HSV). We infected mice lacking the IFN-λ receptor (

Identifiers

PMID37745383
PMCPMC10515813
OpenAlexW4386727839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.