Evidence map›Paper›PMID 37745382›Full record

ArticlebioRxiv : the preprint server for biology2023

Resolving the nanoscale structure of β-sheet assemblies using single-molecule orientation-localization microscopy.

Weiyan Zhou, Conor L O'Neill, Tianben Ding, Oumeng Zhang, Jai S Rudra, Matthew D Lew

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Weiyan ZhouDepartment of Electrical and Systems Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO 63130, USA.
Conor L O'NeillDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO 63130, USA.
Tianben DingDepartment of Electrical and Systems Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO 63130, USA.
Oumeng ZhangDepartment of Electrical and Systems Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO 63130, USA.
Jai S RudraDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO 63130, USA.
Matthew D LewDepartment of Electrical and Systems Engineering, McKelvey School of Engineering, Washington University in St. Louis, MO 63130, USA.

Funding

Six-Dimensional Single-Molecule Nanoscopy for Elucidating the Dynamic Organization of BiomoleculesR35GM124858 · NIGMS · WASHINGTON UNIVERSITY · PI Matthew D Lew · 2017 to 2026
$3.3M
NIGMS NIH HHS R35 GM124858
6 · The paper itself

Abstract

Synthetic peptides that self-assemble into cross-β fibrils have remarkable utility as engineered biomaterials due to their modularity and biocompatibility, but their structural and morphological similarity to amyloid species has been a long-standing concern for their translation. Further, their polymorphs are difficult to characterize using spectroscopic and imaging techniques that rely on ensemble averaging to achieve high resolution. Here, we utilize single-molecule orientation-localization microscopy (SMOLM) to characterize fibrils formed by the designed amphipathic enantiomers, KFE8

Identifiers

PMID37745382
PMCPMC10515885

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.