Evidence map›Paper›PMID 37745379›Full record

ArticlebioRxiv : the preprint server for biology2024

Structural and dynamic changes in P-Rex1 upon activation by PIP

Sandeep K Ravala, Sendi Rafael Adame-Garcia, Sheng Li, Chun-Liang Chen, Michael A Cianfrocco, J Silvio Gutkind, Jennifer N Cash, John J G Tesmer

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sandeep K RavalaDepartments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.
Sendi Rafael Adame-GarciaDepartment of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA 92093, USA.
Sheng LiDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Chun-Liang ChenDepartments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.
Michael A CianfroccoDepartment of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
J Silvio GutkindDepartment of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA 92093, USA.
Jennifer N CashDepartment of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA.ORCID 0000-0002-0277-7652
John J G TesmerDepartments of Biological Sciences and of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0003-1125-3727
Purdue University West Lafayette · USUniversity of California San Diego · USUniversity of California, Davis · USUniversity of Michigan · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5M
Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1M
Regulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, Gβγ and arrestinsR01CA254402 · NCI · PURDUE UNIVERSITY · PI HANDEL, TRACY M, TESMER, JOHN · 2020 to 2024
$3.2M
Structural and Functional Characterization of RhoGEF Regulation Using Nanodiscs to Assemble Membrane-associated Signaling ScaffoldsR35GM146664 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Jennifer Nicole Cash · 2022 to 2026
$2.0M
GPCR - Linked RhoGEFs in Tumor Growth and MetastasisR01CA221289 · NCI · PURDUE UNIVERSITY · PI TESMER, JOHN · 2018 to 2022
$1.9M
NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA221289NCI NIH HHS R01 CA254402NHLBI NIH HHS R01 HL071818NIGMS NIH HHS P30 GM138395NIGMS NIH HHS R35 GM146664
6 · The paper itself

Abstract

PIP

Identifiers

PMID37745379
PMCPMC10515948
OpenAlexW4386804312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.