Evidence map›Paper›PMID 37745358›Full record

ArticlebioRxiv : the preprint server for biology2023

Circadian regulation of

Maria F Gonzalez-Aponte, Anna R Damato, Laura Lucía Trebucq, Tatiana Simon, Sandra P Cárdenas-García, Kevin Cho, Gary J Patti, Diego A Golombek, Juan José Chiesa, Erik D Herzog

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Maria F Gonzalez-AponteDepartment of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-8139-312X
Anna R DamatoDepartment of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-3283-3958
Laura Lucía TrebucqLaboratorio de Cronobiología, Universidad Nacional de Quilmes-CONICET, B1876BXD, Bernal, Buenos Aires, Argentina.ORCID 0000-0002-4126-2125
Tatiana SimonDepartment of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-5686-8798
Sandra P Cárdenas-GarcíaDepartment of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-7001-4446
Kevin ChoDepartments of Chemistry and Medicine, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3041-3506
Gary J PattiDepartments of Chemistry and Medicine, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-3748-6193
Diego A GolombekLaboratorio de Cronobiología, Universidad Nacional de Quilmes-CONICET, B1876BXD, Bernal, Buenos Aires, Argentina.ORCID 0000-0002-6291-5586
Juan José ChiesaLaboratorio de Cronobiología, Universidad Nacional de Quilmes-CONICET, B1876BXD, Bernal, Buenos Aires, Argentina.ORCID 0000-0003-1870-5714
Erik D HerzogDepartment of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-7209-5174
Washington University in St. Louis · USNational University of Quilmes · AR

Funding

MAXIMIZING STUDENT DIVERSITY IN THE BIOMEDICAL SCIENCES AT WASHINGTON UNIVERSITYR25GM103757 · NIGMS · WASHINGTON UNIVERSITY · PI SKEATH, JAMES BENJAMIN · 2013 to 2022
$4.5M
Neuroscience Training Program at Washington UniversityT32NS121881 · NINDS · WASHINGTON UNIVERSITY · PI Martha W Bagnall, Daniel Kerschensteiner · 2021 to 2026
$3.1M
Chronotherapy for glioblastomaR21NS120003 · NINDS · WASHINGTON UNIVERSITY · PI HERZOG, ERIK, RUBIN, JOSHUA B · 2021 to 2022
$433k
Characterization of circadian rhythms in Glioblastoma multiforme and investigation of chronotherapy as a novel therapy to prolong patient survivalF31CA250161 · NCI · WASHINGTON UNIVERSITY · PI DAMATO, ANNA · 2020 to 2022
$82k
NCI NIH HHS F31 CA250161NIGMS NIH HHS R25 GM103757NINDS NIH HHS R21 NS120003NINDS NIH HHS T32 NS121881
6 · The paper itself

Abstract

Background: Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite extensive research and clinical trials, median survival post-treatment remains at 15 months. Thus, all opportunities to optimize current treatments and improve patient outcomes should be considered. A recent retrospective clinical study found that taking TMZ in the morning compared to the evening was associated with a 6-month increase in median survival in patients with Methods and Results: Conclusion: We conclude that chemotherapy with TMZ can be dramatically enhanced by delivering at the daily maximum of tumor

Indexed as

chronotherapycircadian medicinecircadian rhythmsDNA repairGBMTMZ

Identifiers

PMID37745358
PMCPMC10515960
OpenAlexW4386811832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.