Evidence map›Paper›PMID 37745356›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.

Hyun Joo Yoo, Kaoru Nashiro, Shubir Dutt, Jungwon Min, Christine Cho, Julian F Thayer, Paul Lehrer, Catie Chang, Mara Mather

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hyun Joo YooUniversity of Southern California, Los Angeles, CA 90089.
Kaoru NashiroUniversity of Southern California, Los Angeles, CA 90089.
Shubir DuttUniversity of Southern California, Los Angeles, CA 90089.
Jungwon MinUniversity of Southern California, Los Angeles, CA 90089.
Christine ChoUniversity of Southern California, Los Angeles, CA 90089.
Julian F ThayerUniversity of California, Irvine, Irvine, CA 92697.
Paul LehrerRutgers University, NJ 08852.
Catie ChangVanderbilt University, TN 37235.
Mara MatherUniversity of Southern California, Los Angeles, CA 90089.
University of Southern California · USRutgers, The State University of New Jersey · USUniversity of California, Irvine · USVanderbilt University · US

Funding

Why Does Heart Rate Variability Matter for Emotion RegulationR01AG057184 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MATHER, MARA · 2017 to 2021
$2.1M
NIA NIH HHS R01 AG057184
6 · The paper itself

Abstract

Using data from a clinical trial, we tested the hypothesis that daily sessions modulating heart rate oscillations affect older adults' volume of a region-of-interest (ROI) comprised of adjacent hippocampal subregions with relatively strong locus coeruleus (LC) noradrenergic input. Younger and older adults were randomly assigned to one of two daily biofeedback practices for 5 weeks: 1) engage in slow-paced breathing to increase the amplitude of oscillations in heart rate at their breathing frequency (Osc+); 2) engage in self-selected strategies to decrease heart rate oscillations (Osc-). The interventions did not significantly affect younger adults' hippocampal volume. Among older adults, the two conditions affected volume in the LC-targeted hippocampal ROI differentially as reflected in a significant condition x time-point interaction on ROI volume. These condition differences were driven by opposing changes in the two conditions (increased volume in Osc+ and decreased volume in Osc-) and were mediated by the degree of heart rate oscillation during training sessions.

Identifiers

PMID37745356
PMCPMC10516053
OpenAlexW4323351059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.