Evidence map›Paper›PMID 37745322›Full record

ArticlebioRxiv : the preprint server for biology2023

A latent cardiomyocyte regeneration potential in human heart disease.

Wouter Derks, Julian Rode, Sofia Collin, Fabian Rost, Paula Heinke, Anjana Hariharan, Lauren Pickel, Irina Simonova, Enikő Lázár, Evan Graham and 16 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 4 countries.

Wouter DerksCenter for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Julian RodeCenter of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.
Sofia CollinDepartment of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Fabian RostCenter for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Paula HeinkeCenter for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Anjana HariharanCenter for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Lauren PickelCenter for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Irina SimonovaCenter for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Enikő LázárDepartment of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Evan GrahamDepartment of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Ramadan JashariEuropean Homograft Bank, B-1120 Brussels, Belgium.
Michaela AndräDepartment of Cardiothoracic and Vascular Surgery, Klinikum Klagenfurt and Section for Surgical Research Medical University Graz, 9020 Graz, Austria.
Anders JeppssonDepartment of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Mehran SalehpourDepartment of Physics and Astronomy, Applied Nuclear Physics, Uppsala University, SE-751 20 Uppsala, Sweden.
Kanar AlkassDepartment of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden.
Henrik DruidDepartment of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden.
Christos P KyriakopoulosDivisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Iosif TalebDivisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Thirupura S ShankarNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.
Craig H SelzmanDivisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Hesham SadekDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Stefan JovingeSpectrum Health Frederik Meijer Heart & Vascular Institute and Van Andel Institute, Grand Rapids, MI 49503, USA.
Lutz BruschCenter of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.
Jonas FrisénDepartment of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Stavros DrakosDivisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Olaf BergmannCenter for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Technische Universität Dresden · DEKarolinska Institutet · SEUniversity of Utah · USSwedish National Board of Forensic Medicine · SECenter for Systems Biology Dresden · DEKlinikum Klagenfurt · ATSahlgrenska University Hospital · SEThe University of Texas Southwestern Medical Center · USUppsala University · SEVan Andel Institute · US

Funding

CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Perm1 is a Novel Regulator of Cardiac Energetics and FunctionR01HL156667 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI DRAKOS, STAVROS GEORGE, WARREN, JUNKO SHIBAYAMA · 2021 to 2024
$2.0M
Clinical and Metabolic Signature of Recovered Myocardium in Human Heart FailureR01HL135121 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE · 2017 to 2021
$1.9M
Understanding Myocardial Recovery in Diabetes and Heart FailureI01CX002291 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI DRAKOS, STAVROS GEORGE · 2021 to 2025
–
American Heart Association-American Stroke Association 16SFRN29020000CSRD VA I01 CX002291NCATS NIH HHS UM1 TR004409NHLBI NIH HHS R01 HL135121NHLBI NIH HHS R01 HL156667NHLBI NIH HHS T32 HL007576
6 · The paper itself

Abstract

Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective

Identifiers

PMID37745322
PMCPMC10515906
OpenAlexW4386811920

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.