Evidence map›Paper›PMID 37745043›Full record

ReviewExperimental and therapeutic medicine2023

Knee osteoarthritis: Current status and research progress in treatment (Review).

Ruizhi Geng, Jiayi Li, Chen Yu, Chaoqun Zhang, Fei Chen, Jie Chen, Haonan Ni, Jiaxu Wang, Kaiqiang Kang, Ziqi Wei and 2 more

6 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental and therapeutic medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 147 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06594003 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Comparative Study Between Eight Versus Three Genicular Nerves Radiofrequency Ablation for Knee Denervation in Advanced Knee Osteoarthritis Using Ultrasound

TypeinterventionalSponsorAssiut UniversityRan2024 to 2026Enrolled60ConditionsKnee Osteoarthritis \(OA\)ArmsRadiofrequency
NCT06622512 nacompletednot on this mapstarted 2024, after this paper: background citation

Double-Blind Randomized Controlled Trial Comparing the Effectiveness of Two Standardized Radial Pressure Wave Techniques Versus Pain-Site Guided Therapy in Patients With Knee Osteoarthritis.

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2024 to 2025Enrolled82ConditionsOsteoarthritis, KneeArmsRadial Pressure Wave Therapy
NCT06721208 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Development of a Mobile APP to Promote Physical Activity in Individuals With Knee Osteoarthritis: a "Move for Knee" Study Protocol

TypeinterventionalSponsorUniversity of Campania Luigi VanvitelliRan2025 to 2026Enrolled150ConditionsKnee OsteoarthristisArmsuse the "Move for Knee" APP
NCT06986694 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Voodoo Flossing Technique on Pain, Range of Motion and Physical Function in Patients With Knee Osteoarthritis: A Randomized Control Study

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2025Enrolled42ConditionsKnee Osteoarthritis, Pain, Range of Motion, PhysiotherapyArmsGroup A will receive Voodoo Flossing Technique along with aerobic and strengthening exercises & conventional physiotherapy protocol for Knee OA., Group B will receive aerobic and strength training and conventional physiotherapy protocol for knee OA only.
NCT07396233 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis

TypeinterventionalSponsorUniversity of KarachiRan2026 to 2027Enrolled150ConditionsKnee Osteoarthristis, Osteearthritis, Knee Pain ArthritisArmsDiagonal Proprioceptive Neuromuscular Facilitation (PNF) Pattern Exercises, Conventional Strength Training Exercises, Heat Therapy
NCT07402291 nacompletednot on this mapstarted 2025, after this paper: background citation

Comparative Effects of Mulligan's Pain Release Phenomenon and Kaltenborn Mobilizations on Pain, Range of Motion And Disability in Patients With Knee Osteoarthritis.

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2025Enrolled44ConditionsKnee OsteoarthritisArmsMulligan's pain release phenomenon, Kaltenborn mobilization with traction
3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruizhi GengGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Jiayi LiGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Chen YuGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Chaoqun ZhangGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Fei ChenGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Jie ChenGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Haonan NiGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Jiaxu WangGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Kaiqiang KangGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Ziqi WeiGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Yongqing XuGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Tao JinGraduate School, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It is also the most common form of OA and is characterized by high morbidity and disability rates. With the gradual increase in life expectancy and ageing population, KOA not only affects the quality of life of patients, but also poses a burden on global public health. OA is a disease of unknown etiology and complex pathogenesis. It commonly affects joints subjected to greater loads and higher levels of activity. The knee joint, which is the most complex joint of the human body and bears the greatest load among all joints, is therefore most susceptible to development of OA. KOA lesions may involve articular cartilage, synovium, joint capsule and periarticular muscles, causing irreversible articular damage. Factors such as mechanical overload, inflammation, metabolism, hormonal changes and ageing serve key roles in the acceleration of KOA progression. The clinical diagnosis of KOA is primarily based on combined analysis of symptoms, signs, imaging and laboratory examination results. At present, there is no cure for KOA and the currently available therapies primarily focus on symptomatic treatment and delay of disease progression. Knee replacement surgery is typically performed in patients with advanced disease. The current study presents a review of epidemiological characteristics, risk factors, histopathological manifestations, pathogenesis, diagnosis, treatment modalities and progress in KOA research.

Indexed as

arthroplastycartilageconservative treatmentcyclooxygenase 2cytokinedisease progressionglucocorticoidinflammationnon-steroidal anti-inflammatory agentsynovitis

Identifiers

PMID37745043
PMCPMC10515111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.