Evidence map›Paper›PMID 37744993›Full record

ArticleInfluenza and other respiratory viruses2023

Insights into SARS-CoV-2 in Angola during the COVID-19 peak: Molecular epidemiology and genome surveillance.

Ngiambudulu M Francisco, Stephanie van Wyk, Monika Moir, James Emmanuel San, Cruz S Sebastião, Houriiyah Tegally, Joicymara Xavier, Akhil Maharaj, Zoraima Neto, Pedro Afonso and 34 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Ngiambudulu M FranciscoGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.ORCID 0000-0003-3255-8968
Stephanie van WykCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Monika MoirCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
James Emmanuel SanCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Cruz S SebastiãoGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Houriiyah TegallyCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Joicymara XavierCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Akhil MaharajCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Zoraima NetoMinistério da Saúde Luanda Angola.
Pedro AfonsoGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Domingos JandondoGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Joana PaixãoGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Julio MirandaGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Kumbelembe DavidGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Luzia InglêsGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Amilton PereiraGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Agostinho PauloGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Raisa Rivas CarraleroGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.
Helga Reis FreitasDirecção Nacional de Saúde Pública Ministério da Saúde Luanda Angola.
Franco MufindaMinistério da Saúde Luanda Angola.
Silvia LutucutaMinistério da Saúde Luanda Angola.
Mahan GhafariKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban South Africa.
Marta GiovanettiReference Laboratory of Flavivirus Oswaldo Cruz Foundation Rio de Janeiro Brazil.
Jennifer GiandhariKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban South Africa.
Sureshnee PillayKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban South Africa.
Yeshnee NaidooCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Lavanya SinghKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban South Africa.
Derek TshiabuilaCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Darren Patrick MartinDivision of Computational Biology, Department of Integrative Biomedical Sciences University of Cape Town Cape Town South Africa.
Lucious ChabukaCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Wonderful ChogaCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Dorcas WanjohiAfrica CDC Institute of Pathogen Genomics Africa Centre for Disease Control and Prevention Addis Ababa Ethiopia.
Sarah MwangiAfrica CDC Institute of Pathogen Genomics Africa Centre for Disease Control and Prevention Addis Ababa Ethiopia.
Yusasha PillayCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Yenew KebedeAfrica CDC Institute of Pathogen Genomics Africa Centre for Disease Control and Prevention Addis Ababa Ethiopia.
Edwin ShumbaAfrican Society for Laboratory Medicine Addis Ababa Ethiopia.
Pascale OndoaAfrican Society for Laboratory Medicine Addis Ababa Ethiopia.
Cheryl BaxterCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Eduan WilkinsonCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Sofonias Kifle TessemaAfrica CDC Institute of Pathogen Genomics Africa Centre for Disease Control and Prevention Addis Ababa Ethiopia.
Aris KatzourakisDepartment of Biology Oxford University Oxford UK.
Richard LessellsKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Nelson R Mandela School of Medicine University of KwaZulu-Natal Durban South Africa.
Tulio de OliveiraCenter for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa.
Joana MoraisGrupo de Investigação Microbiana e Imunológica Instituto Nacional de Investigação em Saúde Luanda Angola.

Funding

University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3M
Role of Data Streams In Informing Infection Dynamics in Africa- INFORM AfricaU54TW012041 · FIC · INSTITUTE OF HUMAN VIROLOGY · PI Alash'le G. Abimiku, Tulio de Paiva Nazareth Andrade De Oliveira · 2021 to 2026
$6.9M
FIC NIH HHS U54 TW012041NIAID NIH HHS U01 AI151698
6 · The paper itself

Abstract

Background: In Angola, COVID-19 cases have been reported in all provinces, resulting in >105,000 cases and >1900 deaths. However, no detailed genomic surveillance into the introduction and spread of the SARS-CoV-2 virus has been conducted in Angola. We aimed to investigate the emergence and epidemic progression during the peak of the COVID-19 pandemic in Angola. Methods: We generated 1210 whole-genome SARS-CoV-2 sequences, contributing West African data to the global context, that were phylogenetically compared against global strains. Virus movement events were inferred using ancestral state reconstruction. Results: The epidemic in Angola was marked by four distinct waves of infection, dominated by 12 virus lineages, including VOCs, VOIs, and the VUM C.16, which was unique to South-Western Africa and circulated for an extended period within the region. Virus exchanges occurred between Angola and its neighboring countries, and strong links with Brazil and Portugal reflected the historical and cultural ties shared between these countries. The first case likely originated from southern Africa. Conclusion: A lack of a robust genome surveillance network and strong dependence on out-of-country sequencing limit real-time data generation to achieve timely disease outbreak responses, which remains of the utmost importance to mitigate future disease outbreaks in Angola.

Indexed as

COVID-19SARS-CoV-2AngolaHumansMolecular EpidemiologyPandemicsAngolaCOVID‐19genomic surveillanceSARS‐CoV‐2variants of concern

Identifiers

PMID37744993
PMCPMC10515134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.