Evidence map›Paper›PMID 37744936›Full record

ArticleHeart rhythm O22023

Systolic blood pressure ≤110 mm Hg is associated with severe coronary microvascular ischemia and higher risk for ventricular arrhythmias in hypertrophic cardiomyopathy.

Dai-Yin Lu, Hulya Yalcin, Fatih Yalcin, Sanjay Sivalokanathan, Gabriela V Greenland, Ioannis Ventoulis, Styliani Vakrou, Miguel Hernandez Pampaloni, Stefan L Zimmerman, Ines Valenta and 3 more

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In one paragraph

Article in Heart rhythm O2, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dai-Yin LuHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Hulya YalcinHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Fatih YalcinHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Sanjay SivalokanathanHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Gabriela V GreenlandHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Ioannis VentoulisHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Styliani VakrouHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
Miguel Hernandez PampaloniDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Stefan L ZimmermanDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
Ines ValentaDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
Thomas H SchindlerDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland.
Theodore P AbrahamHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.
M Roselle AbrahamHypertrophic Cardiomyopathy Center of Excellence, Johns Hopkins University, Baltimore, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Coronary microvascular dysfunction (CMD) and hypertension (HTN) occur frequently in hypertrophic cardiomyopathy (HCM), but whether blood pressure (BP) influences CMD and outcomes is unknown. Objective: The purpose of this study was to test the hypothesis that HTN is associated with worse CMD and outcomes. Methods: This retrospective study included 690 HCM patients. All patients underwent cardiac magnetic resonance imaging, echocardiography, and rhythm monitoring; 127 patients also underwent rest/vasodilator stress Results: Group 1 patients had the lowest age and left ventricular (LV) mass but the highest prevalence of nonobstructive hemodynamics and restrictive diastolic filling. LV scar was similar in the 3 groups. Group 1 had the lowest rest and stress myocardial blood flow (MBF) and highest SDS (summed difference score). Rest SBP was positively correlated with stress MBF and negatively correlated with SDS. Group 1 had the highest incidence of VT/VF, whereas the incidences of HF, death, and composite outcome were similar among the 3 groups. In multivariate analysis, rest SBP ≤110 mm Hg was independently associated with VT/VF (hazard ratio 2.6; 95% confidence interval 1.0-6.7; Conclusion: SBP ≤110 mm Hg is associated with greater severity of CMD and coronary microvascular ischemia and higher incidence of ventricular arrhythmias in HCM.

Indexed as

Hypertrophic cardiomyopathyMyocardial blood flowRest systolic blood pressureSummed difference scoreVentricular fibrillationVentricular tachycardia

Identifiers

PMID37744936
PMCPMC10513918

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.