Evidence map›Paper›PMID 37744785›Full record

ArticleACS omega2023

Impact of Surface Charge-Tailored Gold Nanorods for Selective Targeting of Mitochondria in Breast Cancer Cells Using Photodynamic Therapy.

Nadar Manimaran Vinita, Umapathy Devan, Sabapathi Durgadevi, Selvaraj Anitha, Muthusamy Govarthanan, Arockiam Antony Joseph Velanganni, Jeyaraman Jeyakanthan, Pitchan Arul Prakash, Mohamed Sultan Mohamed Jaabir, Ponnuchamy Kumar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Decoding the anticancer and biofilm-inhibiting efficacy ofFrontiers in molecular biosciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nadar Manimaran VinitaFood Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.
Umapathy DevanMolecular Oncology Laboratory, Department of Biochemistry, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
Sabapathi DurgadeviFood Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.
Selvaraj AnithaFood Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.
Muthusamy GovarthananDepartment of Environmental Engineering, Kyungpook National University, Deagu 41566, Republic of Korea.
Arockiam Antony Joseph VelanganniMolecular Oncology Laboratory, Department of Biochemistry, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
Jeyaraman JeyakanthanDepartment of Bioinformatics, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.ORCID https://orcid.org/0000-0002-4594-9610
Pitchan Arul PrakashPG and Research Department of Biotechnology and Microbiology, The National College, Tiruchirappalli 620001, Tamil Nadu, India.
Mohamed Sultan Mohamed JaabirPG and Research Department of Biotechnology and Microbiology, The National College, Tiruchirappalli 620001, Tamil Nadu, India.
Ponnuchamy KumarFood Chemistry and Molecular Cancer Biology Lab, Department of Animal Health and Management, Alagappa University, Karaikudi 630 003, Tamil Nadu, India.ORCID https://orcid.org/0000-0003-1496-8840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, the impact of surface charge tailored of gold nanorods (GNRs) on breast cancer cells (MCF-7 and MDA-MB-231) upon conjugation with triphenylphosphonium (TPP) for improved photodynamic therapy (PDT) targeting mitochondria was studied. The salient features of the study are as follows: (i) positive (CTAB@GNRs) and negative (PSS-CTAB@GNRs) surface-charged gold nanorods were developed and characterized; (ii) the mitochondrial targeting efficiency of gold nanorods was improved by conjugating TPP molecules; (iii) the conjugated nanoprobes (TPP-CTAB@GNRs and TPP-PSS-CTAB@GNRs) were evaluated for PDT in the presence of photosensitizer (PS), 5-aminolevulinic acid (5-ALA) in breast cancer cells; (iv) both nanoprobes (TPP-CTAB@GNRs and TPP-PSS-CTAB@GNRs) induce apoptosis, damage DNA, generate reactive oxygen species, and decrease mitochondrial membrane potential upon 5-ALA-based PDT; and (v) 5-ALA-PDT of two nanoprobes (TPP-CTAB@GNRs and TPP-PSS-CTAB@GNRs) impact cell signaling (PI3K/AKT) pathway by upregulating proapoptotic genes and proteins. Based on the results, we confirm that the positively charged (rapid) nanoprobes are more advantageous than their negatively (slow) charged nanoprobes. However, depending on the kind and degree of cancer, both nanoprobes can serve as efficient agents for delivering anticancer therapy.

Identifiers

PMID37744785
PMCPMC10515365

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.