Evidence map›Paper›PMID 37744662›Full record

ArticleCJC open2023

Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium (B-Free): A Protocol for a Multi-centre Randomized Cluster Crossover Trial.

Jessica Spence, Emilie Belley-Côté, Eric Jacobsohn, Shun Fu Lee, Frederick D'Aragon, Michael Avidan, C David Mazer, Nicolas Rousseau-Saine, Raja Rajamohan, Kane Pryor and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CJC open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Remimazolam in the perioperative setting: an answer in search of an ideal question.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Jessica SpenceDepartments of Anesthesia and Critical Care and Health Research Methods, Evaluation, and Impact, McMaster University; and Perioperative Research Division, Population Health Research Institute, Hamilton, Ontario, Canada.
Emilie Belley-CôtéDepartments of Medicine (Cardiology and Critical Care), and Health Research Methods, Evaluation, and Impact, McMaster University, and Perioperative Research Division, Population Health Research Institute, Hamilton, Ontario, Canada.
Eric JacobsohnDepartments of Anesthesia and Perioperative Medicine and Medicine (Critical Care), University of Manitoba, Winnipeg, Manitoba, Canada.
Shun Fu LeeDepartment of Health Research Methods, Evaluation, and Impact, McMaster University, and Population Health Research Institute, Hamilton, Ontario, Canada.
Frederick D'AragonDépartement d'anesthésiologie, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Michael AvidanDepartment of Anesthesia, Washington University at St. Louis, St. Louis, Missouri, USA.
C David MazerDepartment of Anesthesia and Li Ka Shing Knowledge Institute, St. Michael's Hospital, and Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.
Nicolas Rousseau-SaineDépartement d'anesthésiologie, Université de Montréal, Montréal, Quebec, Canada.
Raja RajamohanDepartment of Anesthesia, University of British Columbia, Vancouver, British Columbia, Canada.
Kane PryorDepartment of Anesthesiology, Weill Cornell Medical College, New York, New York, USA.
Rael KleinDepartment of Anesthesia, University of British Columbia, Vancouver, British Columbia, Canada.
Edmund Chong-How TanDepartment of Anesthesia, Dalhousie University, Halifax, Nova Scotia, Canada.
Matthew CameronDepartment of Anesthesia, McGill University, Montreal, Quebec, Canada.
Emily Di SantePopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Erin DeBorbaPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Mary MustardSt. Michael's Hospital, Toronto, Ontario, Canada.
Etienne CoutureDépartement d'anesthésiologie, Université Laval, Quebec City, Quebec, Canada.
Raffael ZamperDepartment of Anesthesia, University of Western Ontario, London, Ontario, Canada.
Michael LawDepartment of Anesthesia, University of British Columbia, Vancouver, British Columbia, Canada.
George DjaianiDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.
Tarit SahaDepartment of Anesthesia, Queen's University, Kingston, Ontario, Canada.
Stephen ChoiDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.
Peter HedlinDepartment of Anesthesia, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Ryan PikalukDepartment of Anesthesia, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Wing Ying LamDepartment of Anesthesia, University of Alberta, Edmonton, Alberta, Canada.
Alain DeschampsDépartement d'anesthésiologie, Université de Montréal, Montréal, Quebec, Canada.
Richard WhitlockDepartments of Surgery (Cardiac Surgery) and Health Research Methods, Evaluation, and Impact, McMaster University, and Perioperative Research Division, Population Health Research Institute, Hamilton, Ontario, Canada.
Braden DulongDepartment of Anesthesia, Dalhousie University, Halifax, Nova Scotia, Canada.
P J DevereauxDepartments of Medicine (Cardiology and Critical Care), and Health Research Methods, Evaluation, and Impact, McMaster University, and Perioperative Research Division, Population Health Research Institute, Hamilton, Ontario, Canada.
Chris BeaverSheridan College, Brampton, Ontario, Canada.
Shelley KloppenburgPopulation Health Research Institute, Hamilton, Ontario, Canada.
Simon OczkowskiDepartment of Medicine (Critical Care), McMaster University, Hamilton, Ontario, Canada.
William Finlay McIntyreDepartment of Medicine (Cardiology), McMaster University, and Perioperative Research Division, Population Health Research Institute, Hamilton, Ontario, Canada.
Matthew McFarlingDepartment of Anesthesia, McMaster University, Hamilton, Ontario, Canada.
Andre LamyDepartments of Surgery (Cardiac Surgery) and Health Research Methods, Evaluation, and Impact, McMaster University, Perioperative Research Division, Population Health Research Institute, Hamilton, Ontario, Canada.
Jessica VincentPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Stuart ConnollyDepartment of Medicine (Cardiology), McMaster University, and Population Health Research Institute, Hamilton, Ontario, Canada.
B-Free Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delirium is common after cardiac surgery and is associated with adverse outcomes. Administration of benzodiazepines before and after cardiac surgery is associated with delirium; guidelines recommend minimizing their use. Benzodiazepine administration during cardiac surgery remains common because of its recognized benefits. The

Identifiers

PMID37744662
PMCPMC10516716

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.