ArticleFrontiers in public health2023
Cost-effectiveness of the Perioperative Pain Management Bundle a registry-based study.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Perceived exertion reflects exercise-induced pain rather than psychological characteristics in recreational endurance athletes.Scientific reports · 2026Article
- Pain Services in the Netherlands: A Cross-Sectional Questionnaire Study on Organisation, Tasks and Responsibilities.Journal of advanced nursing · 2026Article
- Hydrogels and Organogels for Local Anesthetic Delivery: Advances, Challenges, and Translational Perspectives.Gels (Basel, Switzerland) · 2025Review
- The AI and Automation in Anaesthesia (TRIPLE-A) Perioperative Database in Eastern Denmark 2017-: A Platform for Epidemiology, AI-Driven Prediction, Quality Control and Automated Data Retrieval.Acta anaesthesiologica Scandinavica · 2025Article
- Routes of postoperative analgesia administration in surgical wards: practice vs. guidelines and economic implications.Frontiers in medicine · 2025Article
- Sex Is Not an Independent Predictor of Exercise-Induced Pain After Adjustment for Performance and Pain Sensitivity.Pain research & management · 2025Article
- Feedforward Control-Based Bundle Management for Hemoptysis in Pulmonary Tuberculosis Patients.Journal of multidisciplinary healthcare · 2025Article
- Intravenous lidocaine reduces pain intensity and attenuates the increase in plasma norepinephrine levels after hysterectomy.Qatar medical journal · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The Perioperative Pain Management Bundle was introduced in 10 Serbian PAIN OUT network hospitals to improve the quality of postoperative pain management. The Bundle consists of 4 elements: informing patients about postoperative pain treatment options; administering a full daily dose of 1-2 non-opioid analgesics; administering regional blocks and/or surgical wound infiltration; and assessing pain after surgery. In this study, we aimed to assess the cost-effectiveness of the Bundle during the initial 24 h after surgery. Materials and methods: The assessment of cost-effectiveness was carried out by comparing patients before and after Bundle implementation and by comparing patients who received all Bundle elements to those with no Bundle element. Costs of postoperative pain management included costs of the analgesic medications, costs of labor for administering these medications, and related disposable materials. A multidimensional Pain Composite Score (PCS), the effectiveness measurement, was obtained by averaging variables from the International Pain Outcomes questionnaire evaluating pain intensity, interference of pain with activities and emotions, and side effects of analgesic medications. The incremental cost-effectiveness ratio (ICER) was calculated as the incremental change in costs divided by the incremental change in PCS and plotted on the cost-effectiveness plane along with the economic preference analysis. Results: The ICER value calculated when comparing patients before and after Bundle implementation was 181.89 RSD (1.55 EUR) with plotted ICERs located in the northeast and southeast quadrants of the cost-effectiveness plane. However, when comparing patients with no Bundle elements and those with all four Bundle elements, the calculated ICER was -800.63 RSD (-6.82 EUR) with plotted ICERs located in the southeast quadrant of the cost-effectiveness plane. ICER values differ across surgical disciplines. Conclusion: The proposed perioperative pain management Bundle is cost-effective. The cost-effectiveness varies depending on the number of implemented Bundle elements and fluctuates across surgical disciplines.
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