Evidence map›Paper›PMID 37744307›Full record

ArticleJTO clinical and research reports2023

Real-World Treatment Patterns and Outcomes of First-Line Immunotherapy Among Patients With Advanced Nonsquamous NSCLC Harboring

Marina C Garassino, Sabine Oskar, Ashwini Arunachalam, Ke Zu, Yu-Han Kao, Cai Chen, Weilin Meng, M Catherine Pietanza, Bin Zhao, Himani Aggarwal

Abstract read
In one paragraph

Article in JTO clinical and research reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
  4. First-line treatment strategies forJournal of thoracic disease · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Frontiers in oncology · 2024
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marina C GarassinoThoracic Oncology Program, Section of Hematology Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois.
Sabine OskarCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, New Jersey.
Ashwini ArunachalamCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, New Jersey.
Ke ZuEpidemiology, Merck & Co., Inc., Rahway, New Jersey.
Yu-Han KaoCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, New Jersey.
Cai ChenData, AI and Genome Sciences (DAGS) Department, Merck & Co., Inc., Rahway, New Jersey.
Weilin MengCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, New Jersey.
M Catherine PietanzaClinical Research, Merck & Co., Inc., Rahway, New Jersey.
Bin ZhaoClinical Research, Merck & Co., Inc., Rahway, New Jersey.
Himani AggarwalCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Rahway, New Jersey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Data on utilization and clinical outcomes of programmed cell death protein or programmed death-ligand 1 (PD-[L]1) inhibitors in NSCLC with uncommon oncogenic alterations is limited. Methods: This retrospective study used a deidentified U.S. nationwide clinicogenomic database to select patients with advanced nonsquamous NSCLC without Results: Of the 3971 eligible patients, 84 (2%) had NSCLC with Conclusions: Substantial use of anti-PD-(L)1 therapy and associated clinical outcomes are consistent with previous real-world findings and suggest no detriment from PD-(L)1 inhibitors for advanced nonsquamous NSCLC harboring one of these four genomic alterations relative to driver-negative NSCLC.

Indexed as

Advanced non–small cell lung cancerGenomic alterationsImmunotherapyReal-world time on treatmentReal-world time to next treatment

Identifiers

PMID37744307
PMCPMC10514206

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.