Evidence map›Paper›PMID 37744270›Full record

ArticleOncology research2023

Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling.

Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Toshihiko Nogawa, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Kanami Yamazaki and 3 more

Abstract read
In one paragraph

Article in Oncology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Makoto KawataniBiomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.
Harumi AonoChemical Resource Development Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.
Sayoko HiranumaChemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.
Takeshi ShimizuChemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.
Makoto MuroiBiomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.
Toshihiko NogawaMolecular Structure Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.
Tomokazu OhishiInstitute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka, 410-0301, Japan.
Shun-Ichi OhbaInstitute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka, 410-0301, Japan.
Manabu KawadaInstitute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka, 410-0301, Japan.
Kanami YamazakiDivision of Molecular Pharmacology, Cancer Chemotherapy Center, Japan Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Shingo DanDivision of Molecular Pharmacology, Cancer Chemotherapy Center, Japan Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Naoshi DohmaeBiomolecular Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.
Hiroyuki OsadaChemical Resource Development Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science (CSRS), Saitama, 351-0198, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the

Indexed as

Dihydroorotate DehydrogenaseProteomicsCell CycleCell DeathCell Transformation, NeoplasticHumansDihydroorotate DehydrogenaseAnticancer agentsDifferentiating agentsDrug target identification

Identifiers

PMID37744270
PMCPMC10513951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.