Evidence map›Paper›PMID 37744025›Full record

ArticleMedical hypotheses2023

Survival at older ages: are greater influenza antibody titers protective?

Cje Metcalf, S L Klein, J M Read, S Riley, Dat Cummings, Yi Guan, K O Kwok, Z Huachen, C Q Jiang, Tai Hing Lam and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical hypotheses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cje MetcalfDept of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
S L KleinW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
J M ReadDepartment of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, UK.
S RileyMRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK.
Dat CummingsDepartment of Biology, University of Florida, Gainesville, FL, USA.
Yi GuanEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
K O KwokSchool of Public Health, University of Hong Kong, Hong Kong, China.
Z HuachenSchool of Public Health, University of Hong Kong, Hong Kong, China.
C Q JiangGuangzhou No. 12 Hospital, Guangzhou, Guangdong, China.
Tai Hing LamSchool of Public Health, University of Hong Kong, Hong Kong, China.
J LesslerDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Funding

Ecology of Infectious Diseases (EID)-Immune Landscapes of Human Influenza in HousR01TW008246 · FIC · JOHNS HOPKINS UNIVERSITY · PI CUMMINGS, DEREK A · 2008 to 2011
$1.9M
Influenza Immunity and Survival in Aging PopulationsR56AG048075 · NIA · JOHNS HOPKINS UNIVERSITY · PI LESSLER, JUSTIN · 2015 to 2015
$600k
FIC NIH HHS R01 TW008246NIA NIH HHS R56 AG048075
6 · The paper itself

Abstract

Antibodies are a core element of the immune system's defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be modulated by vaccination, these results have important implications for public health policy on influenza control in aging populations.

Indexed as

BiomarkerImmunityInfluenzaSex differenceSurvival

Identifiers

PMID37744025
PMCPMC10512879

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.