Evidence map›Paper›PMID 37744022›Full record

ArticleBrain communications2023

Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington's disease.

Chin-Fu Liu, Laurent Younes, Xiao J Tong, Jared T Hinkle, Maggie Wang, Sanika Phatak, Xin Xu, Xuan Bu, Vivian Looi, Jee Bang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chin-Fu LiuCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
Laurent YounesCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
Xiao J TongDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA.ORCID https://orcid.org/0000-0001-6374-4208
Jared T HinkleDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
Maggie WangCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
Sanika PhatakCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
Xin XuDivision of Magnetic Resonance, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Xuan BuCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
Vivian LooiCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
Jee BangDivision of Neurobiology, Department of Psychiatry, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sarah J TabriziHD Research Centre, University College London Queen Square Institute of Neurology, UCL, London, UK.
Rachael I ScahillHD Research Centre, University College London Queen Square Institute of Neurology, UCL, London, UK.
Jane S PaulsenDepartment of Neurology, University of Wisconsin, Madison, WI 53705, USA.
Nellie Georgiou-KaristianisSchool of Psychological Sciences and The Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria 3800, Australia.ORCID https://orcid.org/0000-0003-0718-6760
Andreia V FariaDivision of Magnetic Resonance, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID https://orcid.org/0000-0002-1673-002X
Michael I MillerCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
J Tilak RatnanatherCenter for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA.
Christopher A RossDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA.

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Validation of Novel Pathogenic Post-Translational Modifications of Huntingtin, and of Modifying Enzymes as Therapeutic Targets for Huntington's DiseaseR01NS086452 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROSS, CHRISTOPHER A · 2014 to 2023
$6.2M
Tracing Spread of Pathology Within The HD Brain via Automated NeuroimagingR01NS102670 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MILLER, MICHAEL I, ROSS, CHRISTOPHER A · 2018 to 2021
$2.4M
NIBIB NIH HHS P41 EB031771NINDS NIH HHS R01 NS086452NINDS NIH HHS R01 NS102670
6 · The paper itself

Abstract

Huntington's disease is caused by a CAG repeat expansion in the Huntingtin gene (

Indexed as

caudateIMAGE-HDPREDICT-HDputamenTRACK-HD

Identifiers

PMID37744022
PMCPMC10516592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.