ArticleToxicology reports2023
The effects of coadministration of curcumin and vitamin E on the reproductive system of diabetic male rats; An experimental study.
Article in Toxicology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- The Impact of Diabetes Mellitus-Related Oxidative Stress on Male Fertility: A Review.Journal of diabetes · 2025Review
- The role of PD-L1 gene silencing on growth, migration, and apoptosis in oral squamous carcinoma cell line HN-5.Annals of medicine and surgery (2012) · 2025Article
- Curcumin as a protective agent for goat sperm viability and DNA integrity against bisphenol A toxicity and cryopreservation stress.Veterinary research communications · 2025Article
- Revolutionizing orthognathic surgery: A clinical case study of an edentulous HCV positive patient utilizing a novel device: A clinical case report.International journal of surgery case reports · 2025Article
- Remarkable healing of a severe wound through surgical debridement, honey medicinal application, amniotic membrane, and bovine collagen powder; A case report study.International journal of surgery case reports · 2025Article
- Partial surgical excision of ewing sarcoma in the lower mandible of an 11-year-old boy with dental malocclusion.Annals of medicine and surgery (2012) · 2025Article
- Mitigation of radiation mediated testicular dysfunction by α-tocopheryl succinate: PPAR-γ related pathway.BMC complementary medicine and therapies · 2025Article
- Surgical debridement and maggot debridement therapy can survive patient with diabetic foot ulcer after foot trauma: A case report.International journal of surgery case reports · 2024Article
- Comprehensive infectious diabetic foot ulcer repair through multiple dressing methods, maggot therapy, and vacuum therapy after amputation: A case report study.International journal of surgery case reports · 2024Article
- Traditional cheese consumption leading to hemodialysis induced by rifampin treatment: A case report.Toxicology reports · 2024Article
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7 authors.
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Abstract
Introduction: Diabetes causes testicular damage due to oxidative stress. Nowadays, the use of vitamins and antioxidants is one of the common methods to treat this disease. Therefore, the aim of this study is to investigate the effect of single and combined administration of these two substances on the reproductive system of male diabetic rats. Method and materials: In this study, 48 adult male Wistar rats weighing 250-270 grammes were divided into 6 groups: Control group, diabetic group, vehicle group, vitamin E, curcumin group, and vitamin E and curcumin group. The control group was the healthy group, and in the other groups, the rats were made diabetic by streptozotocin (60 mg/kg/ip). The vehicle group received 1 ml of olive oil, the vitamin E group (100 mg/kg/ip) received Vit.E, and the curcumin group (50 mg/kg/ip) received Cu. The group of rats received vitamin E and curcumin. At the end of the sixth week after treatment, blood was taken from the rats and biochemical analysis was performed to check the amount of malondialdehyde (MDA), LH hormones and serum testosterone, then the rats were killed and their testes and epididymides were removed. The weight of the testes and sperm parameters, the maturity of sperm nuclei and the integrity of their DNA were checked. The number of spermatogenic cells was determined by histological examination. Results: This study showed that diabetes caused a decrease in testicular weight, sperm count, motility, and viability, an increased percentage of sperm with immature nuclei, and an increased percentage of sperm with denatured DNA. In addition, diabetes decreased the average number of matogenic sperm, and biochemical results showed that diabetes increased the level of MDA and decreased the level of the hormones LH and testosterone. Treatment with vitamin E, curcumin and their combination improved all these parameters, and this improvement was significant in the Toam group. Conclusion: Combined administration of vitamin E and curcumin in diabetic rats significantly improves sperm parameters, matogenic sperm count, and improves MDA levels, LH, and serum testosterone compared with separate treatment.
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