ArticleFrontiers in psychiatry2023
Reduced heart rate variability during mania in a repeated naturalistic observational study.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Feasibility and Acceptability of a Mobile App and Wearable Device for Collecting Mental Health Survey and Passively Sensed Data Among Health Care Workers in Kenya: Mixed Methods Pilot Study.JMIR mHealth and uHealth · 2026Article
- Heart rate variability in unstably housed Veterans with mental health conditions.Journal of clinical and experimental neuropsychology · 2025Article
- OBF-Psychiatric, a motor activity dataset of patients diagnosed with major depression, schizophrenia, and ADHD.Scientific data · 2025Article
- Behavioral manifestations and underlying mechanisms of amphetamine in constructing animal models of mania: a comprehensive review.Frontiers in neuroscience · 2025Review
- A Bayesian analysis of heart rate variability changes over acute episodes of bipolar disorder.Npj mental health research · 2024Article
- Physiological Regularity and Synchrony in Individuals with Gaming Disorder.Entropy (Basel, Switzerland) · 2024Article
- Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation.BMC psychiatry · 2023Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: Bipolar disorder (BD) is a chronic recurrent mood disorder associated with autonomic nervous system (ANS) dysfunction, indexed by heart rate variability (HRV). Changes in HRV between mood states are sparsely studied longitudinally. We aimed to compare HRV of hospitalized manic individuals with their own euthymic selves in a naturalistic observational study. Methods: 34 individuals were included, of which 16 were lost to follow-up. Ultimately 15 patients provided reliable heart rate data in both a manic and euthymic state, using photoplethysmography (PPG) sensor wristbands overnight. We calculated HRV measures Root Mean Square of Successive Differences (RMSSD), High-frequency (HF: 0.15-0.40 Hz), Low-frequency (LF: 0.40-0.15 Hz), Very low-frequency (VLF: 0.0033-0.04 Hz), Total power and Sample Entropy in 5-min night-time resting samples. We compared HRV measures by mood state within individuals using paired Results: HRV was lower in the manic state when compared to the euthymic state for all HRV metrics ( Conclusion: This longitudinal study provides evidence of lower HRV in manic states compared to euthymia, indicating an association between ANS dysregulation and changes in bipolar mood state. This corroborates previous cross-sectional studies, although the association may be less clear or reversed in hypomanic states. Further investigation in larger longitudinal samples is warranted.
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