Observational studyPsychological medicine2023
The association between persistent cognitive difficulties and depression and functional outcomes in people with major depressive disorder.
Observational study in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Associations Between Depressive Symptoms and Memory Functions in Persons with HIV: A Systematic Review and Meta-Analysis.Neuropsychology review · 2026Pooled it
- Systematic Review and Meta-Analysis of the Association Between Subjective and Objective Cognitive Function in Mood Disorders.Bipolar disorders · 2026Pooled it
- Functional connectivity correlates of reaction time variability in treatment-resistant major depression.Psychological medicine · 2026Article
- Prediction of depressive episodes based on clinical features, cognitive characteristics, inflammation-related proteins, and EEG data.Translational psychiatry · 2026Article
- Electroconvulsive therapy and autobiographical memory.Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2026Article
- Patterns and determinants of formal healthcare utilisation among individuals with and without proxy-identified mental health need in Tanzania: A cross-sectional analysis of the National Panel Survey.PLOS mental health · 2026Article
- Heterogeneous impacts of work-family conflict on workforce mental health: evidence from the differential effects of work-to-family and family-to-work conflict.Frontiers in public health · 2026Article
- Cognitive Symptoms and Overall Functioning During Major Depressive Episodes: Correlation Analysis of Patients With Unipolar and Bipolar Disorders.Depression and anxiety · 2026Observational
- Prevalence and associated factors of cognitive impairment among hospitalized older adults with depression: a cross-sectional study from a tertiary psychiatric hospital in Guangzhou, China.Frontiers in public health · 2026Article
- Effects of exercise supplementary to standard therapy on cognition and sleep in depression: a randomised controlled trial.Frontiers in psychiatry · 2026Article
- Sleep, Steps, and Screens: Between- and within-person effects of digital markers of daily life behaviors on smartphone-based assessments of cognitive functioning in depression.Neuroscience applied · 2026Article
- Executive Functions and Subjective Cognitive Decline: The Moderating Role of Depressive Symptoms.Diagnostics (Basel, Switzerland) · 2025Article
- Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.Neuroscience bulletin · 2025Article
- Development and Validation of a Nomogram to Predict Depression Risk in Patients with Cardiovascular Disease.Healthcare (Basel, Switzerland) · 2025Article
- A novel role of the antidepressant paroxetine in inhibiting neuronal Kv7/M channels to enhance neuronal excitability.Translational psychiatry · 2025Article
- Exploring the Impact of Cognitive Dysfunction During Recurrent Depression in a Sample of Mid-to-Older Age British South Asians: A Qualitative Study.Journal of psychiatric and mental health nursing · 2025Article
- The Neural Association Between Symptom and Cognition in Major Depressive Disorder: A Network Control Theory Study.Human brain mapping · 2025Article
- Considering Theory-Based Gamification in the Co-Design and Development of a Virtual Reality Cognitive Remediation Intervention for Depression (bWell-D): Mixed Methods Study.JMIR serious games · 2025Article
- Contribution of physiological dynamics in predicting major depressive disorder severity.Psychophysiology · 2025Article
- Cognitive and motor disturbances in depression: insights from comprehensive behavioral assessments.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive symptoms are common during and following episodes of depression. Little is known about the persistence of self-reported and performance-based cognition with depression and functional outcomes.
methodsThis is a secondary analysis of a prospective naturalistic observational clinical cohort study of individuals with recurrent major depressive disorder (MDD;
results508 individuals (81.5%) provided data (mean age: 46.6, s.d.: 15.6; 76.2% female). Increasing persistence of self-reported cognitive difficulty was associated with higher levels of depression and functional impairment throughout the follow-up. In comparison to low persistence of objective cognitive difficulty (<25% of timepoints), those with high persistence (>75% of timepoints) reported significantly higher levels of depression (
conclusionsWe replicated previous findings of greater persistence of cognitive difficulty with increasing severity of depression and further demonstrate that these cognitive difficulties are associated with pervasive functional disability. Difficulties with cognition may be an indicator and target for further treatment input.
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