Evidence map›Paper›PMID 37743772›Full record

ArticleThe EMBO journal2023

A tryptophan metabolite made by a gut microbiome eukaryote induces pro-inflammatory T cells.

Lukasz Wojciech, Chin Wen Png, Eileen Y Koh, Dorinda Yan Qin Kioh, Lei Deng, Ziteng Wang, Liang-Zhe Wu, Maryam Hamidinia, Desmond Wh Tung, Wei Zhang and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 38 citations in OpenAlex.

  1. Nutrients · 2026
    Trial
  2. Gut microbes · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Decoding Blastocystis-Driven Mechanisms in Gut Microbiota and Host Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. An Update onMicroorganisms · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

Lukasz WojciechImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-8555-834X
Chin Wen PngImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Eileen Y KohDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-9378-6334
Dorinda Yan Qin KiohDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-8612-2417
Lei DengDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ziteng WangDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Liang-Zhe WuImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Maryam HamidiniaImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Desmond Wh TungImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Wei ZhangASEAN Microbiome Nutrition Centre, National Neuroscience Institute, Singapore, Singapore.
Sven PetterssonDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-8903-3738
Eric Chun Yong ChanDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-6107-9072
Yongliang ZhangImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Kevin Sw Tan *Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-9022-729X
Nicholas Rj Gascoigne *Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-9980-4225
National University of Singapore · SGNational Neuroscience Institute · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The large intestine harbors microorganisms playing unique roles in host physiology. The beneficial or detrimental outcome of host-microbiome coexistence depends largely on the balance between regulators and responder intestinal CD4

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsEukaryotaMiceT-Lymphocytes, RegulatoryTryptophanTryptophanaryl hydrocarbon receptorcolitismicrobiomeregulatory T cellstryptophan metabolites

Identifiers

PMID37743772
PMCPMC10620759
OpenAlexW4387001914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.