Evidence map›Paper›PMID 37743677›Full record

SynthesisEndocrinology, diabetes & metabolism2023

Progression of diabetic nephropathy and vitamin D serum levels: A pooled analysis of 7722 patients.

Yomna E Dean, Sameh Samir Elawady, Wangpan Shi, Ahmed A Salem, Arinnan Chotwatanapong, Haya Ashraf, Tharun Reddi, Prashant Obed Reddy Dundi, Waleed Yasser Habash, Mohamed Yasser Habash and 11 more

Open access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Endocrinology, diabetes & metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Vitamin D deficiency and VDRFrontiers in endocrinology · 2025
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 8 countries.

Yomna E DeanFaculty of Medicine, Alexandria University, Alexandria, Egypt.ORCID 0000-0001-6907-0339
Sameh Samir ElawadyNeuro-endovascular Surgery Department, Medical University of South Carolina, Charleston, South Carolina, USA.
Wangpan ShiFaculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ahmed A SalemFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Arinnan ChotwatanapongFaculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Haya AshrafFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Tharun ReddiArkansas College of Osteopathic Medicine, Fort Smith, Arkansas, USA.
Prashant Obed Reddy DundiKarnataka Institute of Medical Sciences, Rajiv Gandhi University of Health Sciences, Bengaluru, India.
Waleed Yasser HabashNew Giza University, Giza, Egypt.
Mohamed Yasser HabashFaculty of Medicine, Kasr Al-Ainy, Cairo University, Cairo, Egypt.
Safaa AhmedFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Hana M SamirFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Ahmed ElsayedFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Aryan AroraSyracuse University, Syracuse, New York, USA.
Abhinav AroraSyracuse University, Syracuse, New York, USA.
Abdelrahman ElsayedCollege of Medicine, Royal College of Surgeons, Dublin, Ireland.
Tamer MadyInternational American University, College of Medicine, Vieux Fort, Saint Lucia.
Yousef TanasFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Yusef HazimehLebanese University, Beirut, Lebanon.ORCID 0000-0002-5090-5997
Mohamed AlazmyMedical director, Dhaman Health Assurance Company, Kuwait, Kuwait.
Hani AiashFaculty of Medicine, Suez Canal University, Ismailia, Egypt.
Suez Canal University · EGAlexandria University · EGCairo University · EGChulalongkorn University · THSyracuse University · USInternational American University · LCKuwait Institute for Medical Specialization · KWLebanese University · LBMedical University of South Carolina · USRajiv Gandhi University of Health Sciences · INUniversity of Arkansas – Fort Smith · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimLow serum Vitamin D levels have been associated with diabetic nephropathy (DN). Our study aimed to analyse the serum levels of vitamin D in patients suffering from DN and the subsequent changes in serum vitamin D levels as the disease progresses.

methodsPubMed, Embase, SCOPUS and Web of Science were searched using keywords such as '25 hydroxyvitamin D' and 'diabetic nephropathy'. We included observational studies that reported the association between the serum 25 hydroxy vitamin D levels and diabetic nephropathy without restriction to age, gender, and location. R Version 4.1.2 was used to perform the meta-analysis. The continuous outcomes were represented as mean difference (MD) and standard deviation (SD) and dichotomous outcomes as risk ratios (RR) with their 95% confidence interval (CI).

resultsTwenty-three studies were included in our analysis with 7722 patients. Our analysis revealed that vitamin D was significantly lower in diabetic patients with nephropathy than those without nephropathy (MD: -4.32, 95% CI: 7.91-0.74, p-value = .0228). On comparing diabetic patients suffering from normoalbuminuria, microalbuminuria, or macroalbuminuria, we found a significant difference in serum vitamin D levels across different groups. Normoalbuminuria versus microalbuminuria showed a MD of -1.69 (95% CI: -2.28 to -1.10, p-value = .0002), while microalbuminuria versus macroalbuminuria showed a MD of (3.75, 95% CI: 1.43-6.06, p-value = .0058), proving that serum vitamin D levels keep declining as the disease progresses. Notwithstanding, we detected an insignificant association between Grade 4 and Grade 5 DN (MD: 2.29, 95% CI: -2.69-7.28, p-value = .1862).

conclusionSerum Vitamin D levels are lower among DN patients and keep declining as the disease progresses, suggesting its potential benefit as a prognostic marker. However, on reaching the macroalbuminuria stage (Grades 4 and 5), vitamin D is no longer a discriminating factor.

Indexed as

Diabetes MellitusDiabetic NephropathiesAlbuminuriaHumansVitamin DVitamin Dalbuminuriadiabetic nephropathyvitamin D

Identifiers

PMID37743677
PMCPMC10638614
OpenAlexW4387002600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.