Evidence map›Paper›PMID 37743460›Full record

SynthesisAnnals of biomedical engineering2024

Making Sense of Electrical Stimulation: A Meta-analysis for Wound Healing.

Mamun Rabbani, Enayetur Rahman, Michael B Powner, Iasonas F Triantis

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07465640 (Evaluating the Efficacy of Pulsating Electromagnetic Field), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07465640 narecruitingnot on this mapstarted 2026, after this paper: background citation

Evaluating the Efficacy of Pulsating Electromagnetic Field (PEMF) Therapy for Diabetic Foot Ulcers Using the CRAD ULCER X-01 Device: A Randomised Parallel-Group Pilot Study

TypeinterventionalSponsorNational Defence University of MalaysiaRan2026 to 2027Enrolled32ConditionsDiabetic Foot Ulcer, Diabetes Mellitus (DM)ArmsPulsating electromagnetic field
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Wearable disposable electrotherapy.Nature communications · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mamun Rabbani *Research Centre for Biomedical Engineering, School of Science and Technology, City University of London, Northampton Square, London, ECIV 0HB, UK.ORCID http://orcid.org/0000-0003-2429-4851
Enayetur Rahman *Research Centre for Biomedical Engineering, School of Science and Technology, City University of London, Northampton Square, London, ECIV 0HB, UK.
Michael B Powner *Centre for Applied Vision Research, School of Health and Psychological Sciences, City University of London, Northampton Square, London, ECIV 0HB, UK.
Iasonas F Triantis *Research Centre for Biomedical Engineering, School of Science and Technology, City University of London, Northampton Square, London, ECIV 0HB, UK. iasonas.triantis.1@city.ac.uk.ORCID http://orcid.org/0000-0002-8900-781X
City, University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical stimulation as a mode of external enhancement factor in wound healing has been explored widely. It has proven to have multidimensional effects in wound healing including antibacterial, galvanotaxis, growth factor secretion, proliferation, transdifferentiation, angiogenesis, etc. Despite such vast exploration, this modality has not yet been established as an accepted method for treatment. This article reviews and analyzes the approaches of using electrical stimulation to modulate wound healing and discusses the incoherence in approaches towards reporting the effect of stimulation on the healing process. The analysis starts by discussing various processes adapted in in vitro, in vivo, and clinical practices. Later it is focused on in vitro approaches directed to various stages of wound healing. Based on the analysis, a protocol is put forward for reporting in vitro works in such a way that the outcomes of the experiment are replicable and scalable in other setups. This work proposes a ground of unification for all the in vitro approaches in a more sensible manner, which can be further explored for translating in vitro approaches to complex tissue stimulation to establish electrical stimulation as a controlled clinical method for modulating wound healing.

Indexed as

Electric Stimulation TherapyWound HealingElectric StimulationIntercellular Signaling Peptides and ProteinsIntercellular Signaling Peptides and ProteinsCurrent of injuryElectrodesElectro-modulationImpedivitySkin woundsStimulation protocolTrans-epithelial potentialWound healing

Identifiers

PMID37743460
PMCPMC10808217
OpenAlexW4386995234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.