Evidence map›Paper›PMID 37743405›Full record

ArticleJournal of the Egyptian National Cancer Institute2023

Micronuclei detection in oral cytologic smear: does it add diagnostic value?

Alaa Elnaggar, Gihane Madkour, Neveen Tahoun, Ayman Amin, Fat'heya M Zahran

Open access · diamondAbstract read
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In one paragraph

Article in Journal of the Egyptian National Cancer Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alaa ElnaggarOral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt. Alaa_hassan@dentistry.cu.edu.eg.ORCID http://orcid.org/0000-0002-5804-0684
Gihane MadkourOral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Neveen TahounNational Cancer Institute, Cairo University, Cairo, Egypt.
Ayman AminNational Cancer Institute, Cairo University, Cairo, Egypt.
Fat'heya M ZahranOral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundScreening and early diagnosis of oral squamous cell carcinoma (OSCC) are directly associated with increased survival rate and improved prognosis. Noninvasive diagnostic tools have been implemented in the early detection as toluidine blue staining, optical imaging, and oral cytology. This study aimed to assess and compare the presence of micronuclei (MN) in oral exfoliative cytology of healthy controls, subjects exposed to high-risk factors for oral cancer, subjects with oral potentially malignant lesions (OPMLs), and those with malignant oral lesions. SUBJECTS AND

methodsA total number of 92 subjects were divided into 46 healthy controls with no oral mucosal lesions (23 with no evidence of cancer risk factors and 23 with cancer risk factors), 23 with OPMLs and 23 with oral malignant lesions. All the 92 participants were subjected to cytological sampling for detection of MN. The final diagnosis of the oral lesions was confirmed by the histopathological picture and compared to the cytological results.

resultsThe results showed that the diagnostic accuracy of MN was higher in OPMLs group (95.2%). The sensitivity of MN test in malignant group was much lower (52.2%); however, all the cytological criteria of malignancy were markedly detected as compared to the OPMLs group.

conclusionsConventional oral cytology supported by MN is highly beneficial as adjunctive tool in the screening for early detection of dysplastic oral lesions.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsHumansRisk FactorsSquamous Cell Carcinoma of Head and NeckExfoliative cytologyMicronucleiOral cancerOral potentially malignant lesions

Identifiers

PMID37743405
PMCPMC13313968
OpenAlexW4386995242

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.