Evidence map›Paper›PMID 37743392›Full record

ArticleScientific reports2023

Cognitive load associates prolonged P300 latency during target stimulus processing in individuals with mild cognitive impairment.

Pinar Demirayak, İlayda Kıyı, Yağmur Özbek İşbitiren, Görsev Yener

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Pinar DemirayakCivitan International Research Center, University of Alabama at Birmingham, 1719 6th Ave S Suite:252B, Birmingham, AL, 35233, USA. pinarde@uab.edu.
İlayda KıyıDepartment of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Turkey.
Yağmur Özbek İşbitirenDepartment of Neurosciences, Institute of Health Sciences, Dokuz Eylül University, İzmir, Turkey.
Görsev YenerBrain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, İzmir, Turkey.
Dokuz Eylül University · TRCivitan International · USİzmir University of Economics · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in P300 amplitude and latency, as well as neuropsychological tests, are informative to detect early signs of the affected high cognitive processing in Mild Cognitive Impairment (MCI). In the present study, we examined P300 latency and amplitude elicited by visual oddball paradigm in 20 participants with MCI and age, education, and sex-matched healthy controls from frontal, central, and parietal midline electrodes. We performed a mixed-design ANOVA to compare P300 amplitude and latency between groups during target and non-target stimulus presentation. We also assessed the correlation between our electrophysiology findings and neuropsychological tests. Our results indicated that in healthy individuals P300 is elicited earlier in target stimulus processing compared to non-target stimulus processing. On the contrary, in the MCI group, P300 latency was increased during target processing compared to non-target stimulus processing. Moreover, P300 latency in target processing is prolonged in the MCI group compared to controls. Also, our correlation results showed a significant correlation between P300 peak latency and amplitude, and attention required cognitive tasks. In conclusion, our results provide evidence that high-order cognitive processes that are involved in stimulus processing slows down in individuals with MCI due to the high working memory demand for neural processing.

Indexed as

Cognitive DysfunctionEvent-Related Potentials, P300AttentionCognitionElectroencephalographyHumansNeuropsychological Tests

Identifiers

PMID37743392
PMCPMC10518304
OpenAlexW4386992104

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.