Evidence map›Paper›PMID 37742664›Full record

ArticleJournal of neonatal-perinatal medicine2023

Clinical impact of analgesic-sedative agents and peri-operative clinical status on white matter brain injury in preterm infants following surgical NEC.

P M Garg, A Rebentisch, M Zhang, J Ware, M Pippins, C Taylor, K Reddy, T Lewis, T E Inder, W B Hillegass

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neonatal-perinatal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

P M GargDepartment of Pediatrics/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, NC, USA.
A RebentischDepartment of Neonatal Pharmacy, University of Mississippi Medical Center, Jackson, MS, USA.
M ZhangDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
J WareDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, MS, USA.
M PippinsDepartment of Pediatrics/Neonatology, University of Mississippi Medical Center, Jackson, MS, USA.
C TaylorDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS, USA.
K ReddyDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS, USA.
T LewisThe Hospital for Sick Children, Divisions of Clinical Pharmacology & Neonatology, Toronto, ON, Canada.
T E InderChildren Hospital of Orange County, University of California, Irvine, Orange, CA, USA.
W B HillegassDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Jackson Memorial Hospital · USUniversity of Mississippi Medical Center · USChildren's Hospital of Orange County · USHospital for Sick Children · CA

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundThe potential influence of exposure to analgesic-sedative agents (ASA) before, during, and after surgical NEC and peri-operative clinical status on white matter injury (WMI) in preterm infants has not been fully defined, and a comprehensive evaluation may inform future research and clinical interventions.

methodsA retrospective study comparing ASA exposure before/during /after surgical NEC and peri-operative clinical status in neonates with and without WMI.

resultsInfants with any WMI (grade 2-4, n = 36/67, 53.7%) had a higher number of surgical procedures receiving ASA (5 [IQR: 3, 8] vs. 3 [2, 4]; p = 0.002) and had a longer duration of hypotension during their first (48.0 hours [26.0, 48.0] vs. 15.5 [6, 48]; p = 0.009) and second surgery (20 hours [0, 48h] vs. 0 [0, 22]; p = 0.017), received more hydrocortisone (35% vs.13.3%,p = 0.04) than those without any WMI. There were no differences in fentanyl/morphine/midazolam exposure before/during/after the NEC onset in the two groups.Infants with severe WMI (19/67, 28.3%, grade 3/4) had a higher incidence of AKI (P = 0.004), surgical morbidity (p = 0.047), more surgical procedures (6.5 [3, 10] vs. 4 [2, 5]; p = 0.012), and received higher mean fentanyl doses(p = 0.03) from birth until NEC onset than those without severe WMI. The univariate associations between these factors and severe WMI remained insignificant after multivariable logistic regression.

conclusionInfants with WMI had more surgical procedures receiving ASA and had a longer duration of hypotension during surgeries. A large multicenter prospective study is needed to understand the full impact of ASA.

Indexed as

Brain InjuriesHypotensionWhite MatterAnalgesicsFentanylHumansHypnotics and SedativesInfantInfant, NewbornInfant, PrematureMagnetic Resonance ImagingRetrospective StudiesAnalgesicsFentanylHypnotics and SedativesAnalgesics-sedativesbrain injuryneonateoutcomespreterm infant

Identifiers

PMID37742664
PMCPMC10615724
OpenAlexW4386955606

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.